Literature DB >> 15273150

Novel antimalarial compounds isolated in a survey of self-medicative behavior of wild chimpanzees in Uganda.

Sabrina Krief1, Marie-Thérèse Martin, Philippe Grellier, John Kasenene, Thierry Sévenet.   

Abstract

Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-directed fractionation provided two new limonoids, trichirubines A and B. A greater understanding of the role of secondary compounds in the primate diet may be helpful in recovering naturally occurring compounds of medicinal significance for human medicine.

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Year:  2004        PMID： 15273150      PMCID： PMC478548          DOI： 10.1128/AAC.48.8.3196-3199.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives.

Authors:  S MacKinnon; T Durst; J T Arnason; C Angerhofer; J Pezzuto; P E Sanchez-Vindas; L J Poveda; M Gbeassor
Journal:  J Nat Prod       Date:  1997-04       Impact factor: 4.050

2.  limonoids from Khaya senegalensis.

Authors:  Sami A. Khalid; Gerda M. Friedrichsen; Arsalan Kharazmi; Thor G. Theander; Carl E. Olsen; S Brøgger Christensen
Journal:  Phytochemistry       Date:  1998-11-20       Impact factor: 4.072

Review 3.  Observational study of behavior: sampling methods.

Authors:  J Altmann
Journal:  Behaviour       Date:  1974       Impact factor: 1.991

4.  In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae).

Authors:  J Bickii; N Njifutie; J A Foyere; L K Basco; P Ringwald
Journal:  J Ethnopharmacol       Date:  2000-01       Impact factor: 4.360

Review 5.  Traditionally-used antimalarials from the Meliaceae.

Authors:  S Omar; J Zhang; S MacKinnon; D Leaman; T Durst; B J R Philogene; J T Arnason; P E Sanchez-Vindas; L Poveda; P A Tamez; J M Pezzuto
Journal:  Curr Top Med Chem       Date:  2003       Impact factor: 3.295

6.  Potential antimalarial candidates from African plants: and in vitro approach using Plasmodium falciparum.

Authors:  S A Khalid; A Farouk; T G Geary; J B Jensen
Journal:  J Ethnopharmacol       Date:  1986-02       Impact factor: 4.360

7.  Human malaria parasites in continuous culture.

Authors:  W Trager; J B Jensen
Journal:  Science       Date:  1976-08-20       Impact factor: 47.728

8.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

9.  A novel natural product compound enhances cAMP-regulated chloride conductance of cells expressing CFTR[delta]F508.

Authors:  Ana C V deCarvalho; Chi P Ndi; Apollinaire Tsopmo; Pierre Tane; Johnson Ayafor; Joseph D Connolly; John L Teem
Journal:  Mol Med       Date:  2002-02       Impact factor: 6.354
  9 in total
  18 in total

1.  World Chimpanzee Day and the Ai's Scarf Award.

Authors:  Tetsuro Matsuzawa
Journal:  Primates       Date:  2018-09       Impact factor: 2.163

2.  Vismione B Interferes with Trypanosoma cruzi Infection of Vero Cells and Human Stem Cell-Derived Cardiomyocytes.

Authors:  Gabriele Sass; Armelle T Tsamo; Gwladys A M Chounda; Pamela K Nangmo; Nazish Sayed; Adriana Bozzi; Joseph C Wu; Augustin E Nkengfack; David A Stevens
Journal:  Am J Trop Med Hyg       Date:  2019-12       Impact factor: 2.345

3.  Investigations on anopheline mosquitoes close to the nest sites of chimpanzees subject to malaria infection in Ugandan highlands.

Authors:  Sabrina Krief; Florence Levrero; Jean-Michel Krief; Supinya Thanapongpichat; Mallika Imwong; Georges Snounou; John M Kasenene; Marie Cibot; Jean-Charles Gantier
Journal:  Malar J       Date:  2012-04-17       Impact factor: 2.979

4.  Geophagy: soil consumption enhances the bioactivities of plants eaten by chimpanzees.

Authors:  Noémie Klein; François Fröhlich; Sabrina Krief
Journal:  Naturwissenschaften       Date:  2008-01-08

5.  Assessment of total phenolic, antioxidant, and antibacterial activities of Passiflora species.

Authors:  Shiamala Devi Ramaiya; Japar Sidik Bujang; Muta Harah Zakaria
Journal:  ScientificWorldJournal       Date:  2014-01-21

Review 6.  Discovery and resupply of pharmacologically active plant-derived natural products: A review.

Authors:  Atanas G Atanasov; Birgit Waltenberger; Eva-Maria Pferschy-Wenzig; Thomas Linder; Christoph Wawrosch; Pavel Uhrin; Veronika Temml; Limei Wang; Stefan Schwaiger; Elke H Heiss; Judith M Rollinger; Daniela Schuster; Johannes M Breuss; Valery Bochkov; Marko D Mihovilovic; Brigitte Kopp; Rudolf Bauer; Verena M Dirsch; Hermann Stuppner
Journal:  Biotechnol Adv       Date:  2015-08-15       Impact factor: 14.227

7.  New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics.

Authors:  Si-Yuan Pan; Shu-Feng Zhou; Si-Hua Gao; Zhi-Ling Yu; Shuo-Feng Zhang; Min-Ke Tang; Jian-Ning Sun; Dik-Lung Ma; Yi-Fan Han; Wang-Fun Fong; Kam-Ming Ko
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-24       Impact factor: 2.629

8.  Seasonal effects on great ape health: a case study of wild chimpanzees and Western gorillas.

Authors:  Shelly Masi; Sophie Chauffour; Odile Bain; Angelique Todd; Jacques Guillot; Sabrina Krief
Journal:  PLoS One       Date:  2012-12-05       Impact factor: 3.240

9.  Mineral Acquisition from Clay by Budongo Forest Chimpanzees.

Authors:  Vernon Reynolds; Andrew W Lloyd; Christopher J English; Peter Lyons; Howard Dodd; Catherine Hobaiter; Nicholas Newton-Fisher; Caroline Mullins; Noemie Lamon; Anne Marijke Schel; Brittany Fallon
Journal:  PLoS One       Date:  2015-07-28       Impact factor: 3.240

10.  The Influence of Seasonal Frugivory on Nutrient and Energy Intake in Wild Western Gorillas.

Authors:  Shelly Masi; Roger Mundry; Sylvia Ortmann; Chloé Cipolletta; Luigi Boitani; Martha M Robbins
Journal:  PLoS One       Date:  2015-07-08       Impact factor: 3.240
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