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Literature DB >> 15273131

In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria.

Amir Braunstein¹, Niv Papo, Yechiel Shai.

Abstract

We report that intravenous injection (3 mg/kg of body weight twice daily) of a diastereomer (containing 33% D amino acids) of an antimicrobial peptide, K6L9 (LKLLKKLLKKLLKLL-NH2), but not the all-L-amino-acid parental peptide, cures neutropenic mice infected with gentamicin-sensitive Pseudomonas aeruginosa and gentamicin-resistant Acinetobacter baumannii bacteria. Various biophysical experiments suggest a membranolytic-like effect.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2004 PMID： 15273131 PMCID： PMC478488 DOI： 10.1128/AAC.48.8.3127-3129.2004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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