Literature DB >> 15271953

Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so.

Matthias Eberl1, Martin Hintz, Zandraa Jamba, Ewald Beck, Hassan Jomaa, Gunna Christiansen.   

Abstract

While most mycoplasma species appear to have evolutionarily lost the ability to synthesize isoprenoid precursors, Mycoplasma penetrans has retained the nonmevalonate pathway that proceeds via the immunogenic intermediate (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells.

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Year:  2004        PMID: 15271953      PMCID: PMC470652          DOI: 10.1128/IAI.72.8.4881-4883.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  14 in total

Review 1.  The changing image of mycoplasmas: from innocent bystanders to emerging and reemerging pathogens in human and animal diseases.

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Journal:  Contrib Microbiol       Date:  2001

2.  The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans.

Authors:  Yuko Sasaki; Jun Ishikawa; Atsushi Yamashita; Kenshiro Oshima; Tsuyoshi Kenri; Keiko Furuya; Chie Yoshino; Atsuko Horino; Tadayoshi Shiba; Tsuguo Sasaki; Masahira Hattori
Journal:  Nucleic Acids Res       Date:  2002-12-01       Impact factor: 16.971

3.  Serological investigation of Mycoplasma genitalium in infertile women.

Authors:  H F Clausen; J Fedder; M Drasbek; P K Nielsen; B Toft; H J Ingerslev; S Birkelund; G Christiansen
Journal:  Hum Reprod       Date:  2001-09       Impact factor: 6.918

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Review 5.  Host-pathogen interactions in mycoplasma pathogenesis: virulence and survival strategies of minimalist prokaryotes.

Authors:  R Rosengarten; C Citti; M Glew; A Lischewski; M Droesse; P Much; F Winner; M Brank; J Spergser
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Review 9.  Microbial isoprenoid biosynthesis and human gammadelta T cell activation.

Authors:  Matthias Eberl; Martin Hintz; Armin Reichenberg; Ann-Kristin Kollas; Jochen Wiesner; Hassan Jomaa
Journal:  FEBS Lett       Date:  2003-06-05       Impact factor: 4.124

10.  The complexity of simplicity.

Authors:  S N Peterson; C M Fraser
Journal:  Genome Biol       Date:  2001-02-08       Impact factor: 13.583

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  11 in total

1.  The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs.

Authors:  Amanda C Brown; Matthias Eberl; Dean C Crick; Hassan Jomaa; Tanya Parish
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2.  Prolonged (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-driven antimicrobial and cytotoxic responses of pulmonary and systemic Vgamma2Vdelta2 T cells in macaques.

Authors:  Zahida Ali; Lingyun Shao; Lisa Halliday; Armin Reichenberg; Martin Hintz; Hassan Jomaa; Zheng W Chen
Journal:  J Immunol       Date:  2007-12-15       Impact factor: 5.422

3.  Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits.

Authors:  Zahida Ali; Lin Yan; Nicholas Plagman; Armin Reichenberg; Martin Hintz; Hassan Jomaa; Francois Villinger; Zheng W Chen
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Review 5.  [Clinical implications of the genus Mycoplasma].

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7.  Persistence of Functional Protein Domains in Mycoplasma Species and their Role in Host Specificity and Synthetic Minimal Life.

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Journal:  Front Cell Infect Microbiol       Date:  2017-02-07       Impact factor: 5.293

8.  A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics.

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Review 9.  Biological functions of IL-17-producing cells in mycoplasma respiratory infection.

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10.  Semi-automated curation of metabolic models via flux balance analysis: a case study with Mycoplasma gallisepticum.

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Journal:  PLoS Comput Biol       Date:  2013-09-05       Impact factor: 4.475

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