Literature DB >> 152715

Adenosine triphosphate and diphosphoglycerate levels in red blood cells from patients with Down's syndrome.

H R Knull, W W Bronstein, P J Porter.   

Abstract

The levels of ATP and ATP plus DPG were significantly elevated in erythrocytes from Down's syndrome patients when compared to erythrocytes from age matched controls. The hemoglobin content and hematocrit values were significantly reduced. The resultant tendency towards anemia probably explains the elevation in metabolite levels.

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Year:  1978        PMID： 152715     DOI： 10.1007/bf01922912

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  18 in total

1.  EFFECT OF ISCHEMIA ON KNOWN SUBSTRATES AND COFACTORS OF THE GLYCOLYTIC PATHWAY IN BRAIN.

Authors:  O H LOWRY; J V PASSONNEAU; F X HASSELBERGER; D W SCHULZ
Journal:  J Biol Chem       Date:  1964-01       Impact factor: 5.157

2.  A comparison of the serotonin and ATP content in platelets from subjects with Down's syndrome.

Authors:  S M Bayer; E E McCoy
Journal:  Biochem Med       Date:  1974-03

3.  Abnormalities of 5-hydroxytryptamine uptake and binding by blood platelets from children with Down's syndrome.

Authors:  D J Boullin; R A O'Brien
Journal:  J Physiol       Date:  1971-01       Impact factor: 5.182

4.  Defective binding of 5-HT by blood platelets from children with the trisomy 21 form of Down's syndrome.

Authors:  D J Boullin; M Coleman; R A O'Brien
Journal:  J Physiol       Date:  1969-10       Impact factor: 5.182

5.  Anemia versus "anemia".

Authors:  H F Bunn
Journal:  N Engl J Med       Date:  1973-02-22       Impact factor: 91.245

6.  Energy metabolism in the brains of L-phenylalanine-treated chicks.

Authors:  S E Granett; W W Wells
Journal:  J Neurochem       Date:  1972-04       Impact factor: 5.372

7.  The effect of volatile anaesthetics on levels of metabolites and on metabolic rate in brain.

Authors:  E A Brunner; J V Passonneau; C Molstad
Journal:  J Neurochem       Date:  1971-12       Impact factor: 5.372

8.  Direct determination of 2,3-diphosphoglycerate.

Authors:  Z B Rose; J Liebowitz
Journal:  Anal Biochem       Date:  1970-05       Impact factor: 3.365

9.  Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin.

Authors:  R Benesch; R E Benesch; C I Yu
Journal:  Proc Natl Acad Sci U S A       Date:  1968-02       Impact factor: 11.205

10.  The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin.

Authors:  R Benesch; R E Benesch
Journal:  Biochem Biophys Res Commun       Date:  1967-01-23       Impact factor: 3.575
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  2 in total

Review 1.  Blood cells: an historical account of the roles of purinergic signalling.

Authors:  Geoffrey Burnstock
Journal:  Purinergic Signal       Date:  2015-08-11       Impact factor: 3.765

Review 2.  Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome.

Authors:  Laszlo Pecze; Elisa B Randi; Csaba Szabo
Journal:  Mol Med       Date:  2020-11-09       Impact factor: 6.354
  2 in total

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