Literature DB >> 26260710

Blood cells: an historical account of the roles of purinergic signalling.

Geoffrey Burnstock1,2.   

Abstract

The involvement of purinergic signalling in the physiology of erythrocytes, platelets and leukocytes was recognised early. The release of ATP and the expression of purinoceptors and ectonucleotidases on erythrocytes in health and disease are reviewed. The release of ATP and ADP from platelets and the expression and roles of P1, P2Y(1), P2Y(12) and P2X1 receptors on platelets are described. P2Y(1) and P2X(1) receptors mediate changes in platelet shape, while P2Y(12) receptors mediate platelet aggregation. The changes in the role of purinergic signalling in a variety of disease conditions are considered. The successful use of P2Y(12) receptor antagonists, such as clopidogrel and ticagrelor, for the treatment of thrombosis, myocardial infarction and stroke is discussed.

Entities:  

Keywords:  ADP; Adenosine; Clopidogrel; Erythrocytes; P2X1; P2Y1; P2Y12; Platelets; Purinoceptor; Thrombosis

Mesh：

Substances：

Year:  2015        PMID： 26260710      PMCID： PMC4648797          DOI： 10.1007/s11302-015-9462-7

Source DB:  PubMed          Journal:  Purinergic Signal        ISSN： 1573-9538            Impact factor:   3.765


  374 in total

Review 1.  Regulation of platelet functions by P2 receptors.

Authors:  Christian Gachet
Journal:  Annu Rev Pharmacol Toxicol       Date:  2006       Impact factor: 13.820

Review 2.  What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O(2) supply within the microvasculature?

Authors:  Christopher G Ellis; Stephanie Milkovich; Daniel Goldman
Journal:  Microcirculation       Date:  2012-07       Impact factor: 2.628

Review 3.  Nucleotide receptors: an emerging family of regulatory molecules in blood cells.

Authors:  F Di Virgilio; P Chiozzi; D Ferrari; S Falzoni; J M Sanz; A Morelli; M Torboli; G Bolognesi; O R Baricordi
Journal:  Blood       Date:  2001-02-01       Impact factor: 22.113

4.  Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase.

Authors:  Madelyn S Hanson; Alan H Stephenson; Elizabeth A Bowles; Randy S Sprague
Journal:  Exp Biol Med (Maywood)       Date:  2010-02

5.  Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.

Authors:  J Jin; J L Daniel; S P Kunapuli
Journal:  J Biol Chem       Date:  1998-01-23       Impact factor: 5.157

6.  Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes.

Authors:  Valérie Tanneur; Christophe Duranton; Verena B Brand; Ciprian D Sandu; Canan Akkaya; Ravi S Kasinathan; Christian Gachet; Ronald Sluyter; Julian A Barden; James S Wiley; Florian Lang; Stephan M Huber
Journal:  FASEB J       Date:  2005-11-02       Impact factor: 5.191

7.  Inhibitory effects of ATP on platelet aggregation: cation interaction and shape change.

Authors:  T Y Wang; C V Hussey; J C Garancis
Journal:  Ann Clin Lab Sci       Date:  1977 Jan-Feb       Impact factor: 1.256

8.  Acetylsalicylic acid inhibits ATP diphosphohydrolase activity by platelets from adult rats.

Authors:  Andréia Buffon; Vanessa B Ribeiro; Cristina R Fürstenau; Ana M O Battastini; João J F Sarkis
Journal:  Clin Chim Acta       Date:  2004-11       Impact factor: 3.786

9.  Does ATP decrease exponentially during red cell aging?

Authors:  M A Lichtman
Journal:  Nouv Rev Fr Hematol       Date:  1975 Nov-Dec

10.  Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation.

Authors:  Sarah Jones; Richard J Evans; Martyn P Mahaut-Smith
Journal:  Br J Haematol       Date:  2011-02-20       Impact factor: 6.998
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  25 in total

1.  Altered extracellular ATP, ADP, and AMP hydrolysis in blood serum of sedentary individuals after an acute, aerobic, moderate exercise session.

Authors:  Cesar Eduardo Jacintho Moritz; Bruno Costa Teixeira; Liliana Rockenbach; Alvaro Reischak-Oliveira; Emerson André Casali; Ana Maria Oliveira Battastini
Journal:  Mol Cell Biochem       Date:  2016-11-16       Impact factor: 3.396

2.  High Level P2X7-Mediated Signaling Impairs Function of Hematopoietic Stem/Progenitor Cells.

Authors:  Wenli Feng; Feifei Yang; Rong Wang; Xiao Yang; Lina Wang; Chong Chen; Jinfeng Liao; Yongmin Lin; Qian Ren; Guoguang Zheng
Journal:  Stem Cell Rev Rep       Date:  2016-06       Impact factor: 5.739

3.  Purinergic control of lysenin's transport and voltage-gating properties.

Authors:  Sheenah Bryant; Nisha Shrestha; Paul Carnig; Samuel Kosydar; Philip Belzeski; Charles Hanna; Daniel Fologea
Journal:  Purinergic Signal       Date:  2016-06-18       Impact factor: 3.765

Review 4.  Purinergic Signalling: Therapeutic Developments.

Authors:  Geoffrey Burnstock
Journal:  Front Pharmacol       Date:  2017-09-25       Impact factor: 5.810

5.  Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood.

Authors:  Brett S Kirby; Matthew A Sparks; Eduardo R Lazarowski; Denise A Lopez Domowicz; Hongmei Zhu; Timothy J McMahon
Journal:  Am J Physiol Heart Circ Physiol       Date:  2021-01-15       Impact factor: 4.733

6.  The role of purinergic P2Y12 and P2Y13 receptors in ADPβS-induced inhibition of the cardioaccelerator sympathetic drive in pithed rats.

Authors:  Belinda Villanueva-Castillo; Eduardo Rivera-Mancilla; Kristian Agmund Haanes; Antoinette MaassenVanDenBrink; Carlos M Villalón
Journal:  Purinergic Signal       Date:  2020-02-17       Impact factor: 3.765

Review 7.  Short- and long-term (trophic) purinergic signalling.

Authors:  Geoffrey Burnstock
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-08-05       Impact factor: 6.237

Review 8.  Involvement of P2 receptors in hematopoiesis and hematopoietic disorders, and as pharmacological targets.

Authors:  Kelly Juliana Filippin; Kamylla F S de Souza; Roberto Theodoro de Araujo Júnior; Heron Fernandes Vieira Torquato; Dhébora Albuquerque Dias; Eduardo Benedetti Parisotto; Alice Teixeira Ferreira; Edgar J Paredes-Gamero
Journal:  Purinergic Signal       Date:  2019-12-20       Impact factor: 3.765

9.  ADP receptor P2y12 prevents excessive primitive hematopoiesis in zebrafish by inhibiting Gata1.

Authors:  Fang-Fang Li; Yu-Lai Liang; Xiao-Shuai Han; Ya-Na Guan; Jian Chen; Ping Wu; Xian-Xian Zhao; Qing Jing
Journal:  Acta Pharmacol Sin       Date:  2020-06-17       Impact factor: 6.150

Review 10.  Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling-an update.

Authors:  Mariusz Z Ratajczak; Mateusz Adamiak; Kamila Bujko; Arjun Thapa; Valentina Pensato; Magda Kucia; Janina Ratajczak; Henning Ulrich
Journal:  Purinergic Signal       Date:  2020-05-15       Impact factor: 3.765
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