PURPOSE: In a previous study we reported clinically significant memory declines 3 months after selective amygdalohippocampectomy (SAH) in 140 patients with mesial temporal lobe epilepsy, particularly if the resection was left-sided. We supposed that the observed postoperative impairments might have reflected acute effects of surgery. Therefore we evaluated in the present study whether a recovery can be found 1 year after surgery. METHODS: Verbal and nonverbal memory functions were assessed in 115 patients before and 3 and 12 months after unilateral SAH. RESULTS: No recovery of postoperative verbal memory declines was found in the left-SAH group. Clinically meaningful losses were still evident in 33 to 50% of patients. In right-SAH patients, a recovery of verbal memory was indicated, and effects of surgical complications were no longer evident. One year after surgery, the corresponding preoperative performance was the only significant predictor of a postoperative change in the left-SAH group. CONCLUSIONS: Verbal memory decline observed 3 months after left SAH is persistent 1 year after surgery. Declines in verbal memory, which were observed in some right-SAH patients at the short-term follow-up, seem to be temporary.
PURPOSE: In a previous study we reported clinically significant memory declines 3 months after selective amygdalohippocampectomy (SAH) in 140 patients with mesial temporal lobe epilepsy, particularly if the resection was left-sided. We supposed that the observed postoperative impairments might have reflected acute effects of surgery. Therefore we evaluated in the present study whether a recovery can be found 1 year after surgery. METHODS: Verbal and nonverbal memory functions were assessed in 115 patients before and 3 and 12 months after unilateral SAH. RESULTS: No recovery of postoperative verbal memory declines was found in the left-SAH group. Clinically meaningful losses were still evident in 33 to 50% of patients. In right-SAHpatients, a recovery of verbal memory was indicated, and effects of surgical complications were no longer evident. One year after surgery, the corresponding preoperative performance was the only significant predictor of a postoperative change in the left-SAH group. CONCLUSIONS: Verbal memory decline observed 3 months after left SAH is persistent 1 year after surgery. Declines in verbal memory, which were observed in some right-SAHpatients at the short-term follow-up, seem to be temporary.
Authors: Jeffrey R Binder; David S Sabsevitz; Sara J Swanson; Thomas A Hammeke; Manoj Raghavan; Wade M Mueller Journal: Epilepsia Date: 2008-04-24 Impact factor: 5.864
Authors: Andréa Alessio; Fabricio R S Pereira; Maurício S Sercheli; Jane M Rondina; Helka B Ozelo; Elisabeth Bilevicius; Tatiane Pedro; Roberto J M Covolan; Benito P Damasceno; Fernando Cendes Journal: Hum Brain Mapp Date: 2011-10-31 Impact factor: 5.038
Authors: Juri-Alexander Witt; Roland Coras; Johannes Schramm; Albert J Becker; Christian E Elger; Ingmar Blümcke; Christoph Helmstaedter Journal: J Neurol Date: 2015-07-03 Impact factor: 4.849
Authors: Jeffrey R Binder; Sara J Swanson; David S Sabsevitz; Thomas A Hammeke; Manoj Raghavan; Wade M Mueller Journal: Epilepsia Date: 2009-10-08 Impact factor: 5.864