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Literature DB >> 152707

Delayed cutaneous hypersensitivity in children with severe multiple handicaps treated with phenytoin.

A Higashi, I Matsuda, S Sinosuka, H Ohtsuka, F Endo, T Maeda, T Ikeda, S Miyoshino.

Abstract

Peripheral lymphocyte counts, T-cell and B-cell populations, DNCB skin reactions, Mantoux reactions, mitogenic transformation using PHA, and determination of serum phenytoin concentration were carried out in 45 children with severe handicaps. Twenty two of these patients were receiving phenytoin treatment. When compared with control subjects, the skin reactions were significantly depressed in the handicapped children, amongst whom those treated with phenytoin had more impaired reactions than those who were untreated. No significant relationship between the results of the skin reactions and the other parameters was found.

Entities: Chemical Disease Species

Mesh：

Substances：
Phenytoin

Year: 1978 PMID： 152707 DOI： 10.1007/bf00441358

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

14 in total

1. Partial DiGeorge syndrome with substantial cell-mediated immunity.

Authors: H F Pabst; W C Wright; J LeRiche; E R Stiehm
Journal: Am J Dis Child Date: 1976-03

2. Human lymphocyte subpopulations. Human thymus-lymphoid tissue (HTL) antigen-positive lymphocytes forming rosettes with sheep erythrocytes and HTL antigen-negative lymphocytes interacting with antigen-antibody-complement complexes.

Authors: J Yata; I Tsukimoto; T Tachibana
Journal: Clin Exp Immunol Date: 1973-07 Impact factor: 4.330

4. Association of increased numbers of peripheral blood double-negative T-lymphocytes with elevated serum IgG levels in severely handicapped children.

Authors: Y Kawano; T Noma; I Yoshizawa; K Maruki; J Yata
Journal: Eur J Pediatr Date: 1994-12 Impact factor: 3.183

4 in total

Delayed cutaneous hypersensitivity in children with severe multiple handicaps treated with phenytoin.

1. Partial DiGeorge syndrome with substantial cell-mediated immunity.

2. Human lymphocyte subpopulations. Human thymus-lymphoid tissue (HTL) antigen-positive lymphocytes forming rosettes with sheep erythrocytes and HTL antigen-negative lymphocytes interacting with antigen-antibody-complement complexes.

3. Maturation of cell-surface structure of human B lymphocytes.

4. Diphenylhydantoin effects on human lymphocytes in vitro and in vivo. An hypothesis to explain some drug reactions.

5. A rapid assay of cell mediated immunity to soluble antigens based on the stimulation of protein synthesis.

6. Letter: Lymphocytopenia in patients treated with phenytoin.

7. Letter: Immunosuppression by phenytoin.

8. Selective diphenylhydantoin-induced suppression of lymphocyte reactivity in vitro.

9. Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).

10. Immunological abnormalities and hydantoins.

1. Reports of two cases of autoimmune thyroiditis while receiving anticonvulsant therapy.

2. Response to transfer factor to immunodeficiency in handicaps treated with phenytoin.

3. Immunological study of IgA deficiency during anticonvulsant therapy in epileptic patients.

4. Association of increased numbers of peripheral blood double-negative T-lymphocytes with elevated serum IgG levels in severely handicapped children.