Literature DB >> 15269205

The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis.

Ruslan Sanishvili1, Steven Beasley, Tania Skarina, David Glesne, Andrzej Joachimiak, Aled Edwards, Alexei Savchenko.   

Abstract

The crystal structure of Escherichia coli MoaB was determined by multiwavelength anomalous diffraction phasing and refined at 1.6-A resolution. The molecule displayed a modified Rossman fold. MoaB is assembled into a hexamer composed of two trimers. The monomers have high structural similarity with two proteins, MogA and MoeA, from the molybdenum cofactor synthesis pathway in E. coli, as well as with domains of mammalian gephyrin and plant Cnx1, which are also involved in molybdopterin synthesis. Structural comparison between these proteins and the amino acid conservation patterns revealed a putative active site in MoaB. The structural analysis of this site allowed to advance several hypothesis that can be tested in further studies.

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Year:  2004        PMID： 15269205      PMCID： PMC3366512          DOI： 10.1074/jbc.M407694200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  43 in total

1.  The Protein Data Bank.

Authors:  H M Berman; J Westbrook; Z Feng; G Gilliland; T N Bhat; H Weissig; I N Shindyalov; P E Bourne
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

Review 2.  Genetics of molybdenum cofactor deficiency.

Authors:  J Reiss
Journal:  Hum Genet       Date:  2000-02       Impact factor: 4.132

3.  The finer things in X-ray diffraction data collection.

Authors:  J W Pflugrath
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1999-10

4.  Automated protein model building combined with iterative structure refinement.

Authors:  A Perrakis; R Morris; V S Lamzin
Journal:  Nat Struct Biol       Date:  1999-05

5.  Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli.

Authors:  M T Liu; M M Wuebbens; K V Rajagopalan; H Schindelin
Journal:  J Biol Chem       Date:  2000-01-21       Impact factor: 5.157

6.  Hypersensitivity of Escherichia coli Delta(uvrB-bio) mutants to 6-hydroxylaminopurine and other base analogs is due to a defect in molybdenum cofactor biosynthesis.

Authors:  S G Kozmin; Y I Pavlov; R L Dunn; R M Schaaper
Journal:  J Bacteriol       Date:  2000-06       Impact factor: 3.490

Review 7.  Molybdenum enzymes.

Authors:  R Hille
Journal:  Essays Biochem       Date:  1999       Impact factor: 8.000

8.  Insights into molybdenum cofactor deficiency provided by the crystal structure of the molybdenum cofactor biosynthesis protein MoaC.

Authors:  M M Wuebbens; M T Liu; K Rajagopalan; H Schindelin
Journal:  Structure       Date:  2000-07-15       Impact factor: 5.006

9.  The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis.

Authors:  M W Lake; C A Temple; K V Rajagopalan; H Schindelin
Journal:  J Biol Chem       Date:  2000-12-22       Impact factor: 5.157

10.  Diversity and phylogeny of gephyrin: tissue-specific splice variants, gene structure, and sequence similarities to molybdenum cofactor-synthesizing and cytoskeleton-associated proteins.

Authors:  M Ramming; S Kins; N Werner; A Hermann; H Betz; J Kirsch
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-29       Impact factor: 11.205
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  11 in total

1.  Crystal structures, dynamics and functional implications of molybdenum-cofactor biosynthesis protein MogA from two thermophilic organisms.

Authors:  Shankar Prasad Kanaujia; Jeyaraman Jeyakanthan; Akeo Shinkai; Seiki Kuramitsu; Shigeyuki Yokoyama; Kanagaraj Sekar
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-12-21

2.  Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) from Sulfolobus tokodaii.

Authors:  Svetlana V Antonyuk; Richard W Strange; Mark J Ellis; Yoshitaka Bessho; Seiki Kuramitsu; Akeo Shinkai; Shigeyuki Yokoyama; S Samar Hasnain
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-11-27

3.  Overexpression, purification, crystallization and preliminary X-ray analysis of putative molybdenum cofactor biosynthesis protein C (MoaC2) from Mycobacterium tuberculosis H37Rv.

Authors:  Shubhra Srivastava; Vijay Kumar Srivastava; Ashish Arora; J Venkatesh Pratap
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-05-23

4.  Genetic characterization of moaB mutants of Escherichia coli.

Authors:  Stanislav G Kozmin; Roel M Schaaper
Journal:  Res Microbiol       Date:  2013-05-13       Impact factor: 3.992

5.  Structure of a putative molybdenum-cofactor biosynthesis protein C (MoaC) from Sulfolobus tokodaii (ST0472).

Authors:  Hiromi Yoshida; Mitsugu Yamada; Seiki Kuramitsu; Shigehiro Kamitori
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-06-11

6.  Crystal structure of Bacillus subtilis YckF: structural and functional evolution.

Authors:  R Sanishvili; R Wu; D E Kim; J D Watson; F Collart; A Joachimiak
Journal:  J Struct Biol       Date:  2004-10       Impact factor: 2.867

7.  A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism.

Authors:  Elizabeth E Regulski; Ryan H Moy; Zasha Weinberg; Jeffrey E Barrick; Zizhen Yao; Walter L Ruzzo; Ronald R Breaker
Journal:  Mol Microbiol       Date:  2008-03-19       Impact factor: 3.501

8.  Genomics-guided analysis of NAD recycling yields functional elucidation of COG1058 as a new family of pyrophosphatases.

Authors:  Lucia Cialabrini; Silverio Ruggieri; Marat D Kazanov; Leonardo Sorci; Francesca Mazzola; Giuseppe Orsomando; Andrei L Osterman; Nadia Raffaelli
Journal:  PLoS One       Date:  2013-06-12       Impact factor: 3.240

9.  Acid stress response and protein induction in Campylobacter jejuni isolates with different acid tolerance.

Authors:  Tina Birk; Monica Takamiya Wik; René Lametsch; Susanne Knøchel
Journal:  BMC Microbiol       Date:  2012-08-13       Impact factor: 3.605

10.  Structural basis of thermal stability of the tungsten cofactor synthesis protein MoaB from Pyrococcus furiosus.

Authors:  Nastassia Havarushka; Katrin Fischer-Schrader; Tobias Lamkemeyer; Guenter Schwarz
Journal:  PLoS One       Date:  2014-01-20       Impact factor: 3.240
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