Literature DB >> 15266124

Combining induced mutation and protoplasting for strain improvement of Aspergillus oryzae for kojic acid production.

Hisao-Ming Wan1, Chien-Chiang Chen, Te-Sheng Chang, Raghavan N Giridhar, Wen-Teng Wu.   

Abstract

By combining induced mutation, using NTG and UV irradiation, and protoplasting of a wild type strain of Aspergillus oryzae ATCC 22788, a hyper-producing strain was obtained that accumulated 41 g kojic acid l(-1) in shake-flasks, which was 100-fold higher than that in the wild type strains. Similar production of kojic acid was obtained in 5 l stirred-tank fermentations.

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Year:  2004        PMID： 15266124     DOI： 10.1023/B:BILE.0000035490.49252.38

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  5 in total

1.  Repeated-batch production of kojic acid in a cell-retention fermenter using Aspergillus oryzae M3B9.

Authors:  H M Wan; C C Chen; R Giridhar; T S Chang; W T Wu
Journal:  J Ind Microbiol Biotechnol       Date:  2005-05-14       Impact factor: 3.346

Review 2.  Metabolic regulation and overproduction of primary metabolites.

Authors:  Sergio Sanchez; Arnold L Demain
Journal:  Microb Biotechnol       Date:  2008-07       Impact factor: 5.813

3.  Improved production of kojic acid by mutagenesis of Aspergillus flavus HAk1 and Aspergillus oryzae HAk2 and their potential antioxidant activity.

Authors:  Hala A M Ammar; Saeid M Ezzat; Asmaa M Houseny
Journal:  3 Biotech       Date:  2017-08-04       Impact factor: 2.406

4.  Synthesis and Evaluation of Dodecaboranethiol Containing Kojic Acid (KA-BSH) as a Novel Agent for Boron Neutron Capture Therapy.

Authors:  Koji Takeuchi; Yoshihide Hattori; Shinji Kawabata; Gen Futamura; Ryo Hiramatsu; Masahiko Wanibuchi; Hiroki Tanaka; Shin-Ichiro Masunaga; Koji Ono; Shin-Ichi Miyatake; Mitsunori Kirihata
Journal:  Cells       Date:  2020-06-25       Impact factor: 6.600

5.  Aspergillus oryzae-based cell factory for direct kojic acid production from cellulose.

Authors:  Ryosuke Yamada; Toshihide Yoshie; Satoshi Wakai; Nanami Asai-Nakashima; Fumiyoshi Okazaki; Chiaki Ogino; Hiromoto Hisada; Hiroko Tsutsumi; Yoji Hata; Akihiko Kondo
Journal:  Microb Cell Fact       Date:  2014-05-18       Impact factor: 5.328
  5 in total

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