Human Herpesvirus 6 Infection of the Central Nervous System.

Human herpesvirus (HHV) 6 infects all children, usually during the first year of life. High fever is the hallmark of primary infection, with febrile seizures the most common complication. After primary infection, HHV-6 remains latent or persistent at multiple sites, with intermittent reactivation. Many disorders of the central nervous system (CNS) have been linked to HHV-6 reactivation, including chronic seizure disorders, encephalitis, and demyelinating disorders including multiple sclerosis. Although multiple studies have pieced together an understanding of the molecular organization, viral characteristics, immunology, and epidemiology of HHV-6, the true role of this virus in diseases of the CNS is still unfolding.