Literature DB >> 15264436

Technology evaluation: ISIS-113715, Isis.

Gang Liu1.   

Abstract

Isis is developing ISIS-113715, an antisense inhibitor of the PTP1B gene, for the potential treatment of type 2 diabetes and obesity. ISIS-113715 is undergoing phase II clinical trials.

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Year:  2004        PMID： 15264436

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  11 in total

1.  PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.

Authors:  Laurent Lessard; David P Labbé; Geneviève Deblois; Louis R Bégin; Serge Hardy; Anne-Marie Mes-Masson; Fred Saad; Lloyd C Trotman; Vincent Giguère; Michel L Tremblay
Journal:  Cancer Res       Date:  2012-01-26       Impact factor: 12.701

Review 2.  Chemical modification: the key to clinical application of RNA interference?

Authors:  David R Corey
Journal:  J Clin Invest       Date:  2007-12       Impact factor: 14.808

Review 3.  Inside the human cancer tyrosine phosphatome.

Authors:  Sofi G Julien; Nadia Dubé; Serge Hardy; Michel L Tremblay
Journal:  Nat Rev Cancer       Date:  2011-01       Impact factor: 60.716

4.  A sesquiterpene quinone, dysidine, from the sponge Dysidea villosa, activates the insulin pathway through inhibition of PTPases.

Authors:  Yu Zhang; Yan Li; Yue-wei Guo; Hua-liang Jiang; Xu Shen
Journal:  Acta Pharmacol Sin       Date:  2009-03       Impact factor: 6.150

Review 5.  Targeting hepatic glucose metabolism in the treatment of type 2 diabetes.

Authors:  Amy K Rines; Kfir Sharabi; Clint D J Tavares; Pere Puigserver
Journal:  Nat Rev Drug Discov       Date:  2016-08-12       Impact factor: 84.694

6.  (+)-Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice.

Authors:  Yu Zhang; Haitao Zhang; Xin-Gang Yao; Hong Shen; Jing Chen; Chenjing Li; Lili Chen; Mingyue Zheng; Jiming Ye; Lihong Hu; Xu Shen; Hualiang Jiang
Journal:  PLoS One       Date:  2012-02-27       Impact factor: 3.240

7.  Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice.

Authors:  Jing Sun; Yongsen Wang; Xueqi Fu; Yingli Chen; Deli Wang; Wannan Li; Shu Xing; Guodong Li
Journal:  Biomed Res Int       Date:  2015-05-07       Impact factor: 3.411

8.  Protein tyrosine phosphatases: new markers and targets in oncology?

Authors:  S Hardy; M L Tremblay
Journal:  Curr Oncol       Date:  2008-01       Impact factor: 3.677

9.  The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity.

Authors:  David Medgyesi; Elias Hobeika; Robert Biesen; Florian Kollert; Adriano Taddeo; Reinhard E Voll; Falk Hiepe; Michael Reth
Journal:  J Exp Med       Date:  2014-03-03       Impact factor: 14.307

10.  Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice.

Authors:  Jing Sun; Xueqi Fu; Ye Liu; Yongsen Wang; Bo Huo; Yidi Guo; Xuefeng Gao; Wannan Li; Xin Hu
Journal:  Drug Des Devel Ther       Date:  2015-12-04       Impact factor: 4.162
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