Padmini Srinivasan1, Bisharah Libbus. 1. School of Library and Information Science, University of Iowa, Iowa City, IA 52242, USA. padmini-srinivasan@uiowa.edu
Abstract
MOTIVATION: Text mining systems aim at knowledge discovery from text collections. This work presents our text mining algorithm and demonstrates its use to uncover information that could form the basis of new hypotheses. In particular, we use it to discover novel uses for Curcuma longa, a dietary substance, which is highly regarded for its therapeutic properties in Asia. RESULTS: Several disease were identified that offer novel research contexts for curcumin. We analyze select suggestions, such as retinal diseases, Crohn's disease and disorders related to the spinal cord. Our analysis suggests that there is strong evidence in favor of a beneficial role for curcumin in these diseases. The evidence is based on curcumin's influence on several genes, such as COX-2, TNF-alpha, JNK, p38 MAPK and TGF-beta. This research suggests that our discovery algorithm may be used to suggest novel uses for dietary and pharmacological substances. More generally, our text mining algorithm may be used to uncover information that potentially sheds new light on a given topic of interest. AVAILABILITY: Contact authors.
MOTIVATION: Text mining systems aim at knowledge discovery from text collections. This work presents our text mining algorithm and demonstrates its use to uncover information that could form the basis of new hypotheses. In particular, we use it to discover novel uses for Curcuma longa, a dietary substance, which is highly regarded for its therapeutic properties in Asia. RESULTS: Several disease were identified that offer novel research contexts for curcumin. We analyze select suggestions, such as retinal diseases, Crohn's disease and disorders related to the spinal cord. Our analysis suggests that there is strong evidence in favor of a beneficial role for curcumin in these diseases. The evidence is based on curcumin's influence on several genes, such as COX-2, TNF-alpha, JNK, p38 MAPK and TGF-beta. This research suggests that our discovery algorithm may be used to suggest novel uses for dietary and pharmacological substances. More generally, our text mining algorithm may be used to uncover information that potentially sheds new light on a given topic of interest. AVAILABILITY: Contact authors.
Authors: Rein Vos; Sil Aarts; Erik van Mulligen; Job Metsemakers; Martin P van Boxtel; Frans Verhey; Marjan van den Akker Journal: J Am Med Inform Assoc Date: 2013-06-17 Impact factor: 4.497
Authors: John D Osborne; Jared Flatow; Michelle Holko; Simon M Lin; Warren A Kibbe; Lihua Julie Zhu; Maria I Danila; Gang Feng; Rex L Chisholm Journal: BMC Genomics Date: 2009-07-07 Impact factor: 3.969