| Literature DB >> 15262427 |
Cristina Morerio1, Annamaria Rapella, Cristina Rosanda, Edoardo Lanino, Luca Lo Nigro, Andrea Di Cataldo, Emanuela Maserati, Francesco Pasquali, Claudio Panarello.
Abstract
Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.Entities:
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Year: 2004 PMID： 15262427 DOI： 10.1016/j.cancergencyto.2003.11.012
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608