Literature DB >> 15261267

Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents.

Pratibha Sharma1, Nilesh Rane, V K Gurram.   

Abstract

A number of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives were synthesized and screened for antibacterial and antifungal activities. All the synthesized compounds showed the potent antimicrobial activity. The quantitative structure-activity relationship investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.

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Year:  2004        PMID： 15261267     DOI： 10.1016/j.bmcl.2004.06.014

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  32 in total

1.  Design, Synthesis and Biological Evaluation of Novel Pyrimido[4,5-d]pyrimidine CDK2 Inhibitors as Anti-Tumor Agents.

Authors:  Samir M El-Moghazy; Diaa A Ibrahim; Nagwa M Abdelgawad; Nahla A H Farag; Ahmad S El-Khouly
Journal:  Sci Pharm       Date:  2011-05-08

2.  Synthesis, X-ray and Fluorescence Characteristics of Pyrimido[5,4-e]thiazolo[3,2-a]pyrimidine as a Novel Heterocyclic System.

Authors:  Zahra Ebrahimpour; Mehdi Bakavoli; Ali Shiri; Seyed Mohammad Seyedi; Tayebe Asghari; Joel T Mague
Journal:  J Fluoresc       Date:  2017-03-10       Impact factor: 2.217

3.  Preparation of tetrasubstituted pyrimido[4,5-d]pyrimidine diones.

Authors:  Hui Wang; Chao Wang; Thomas D Bannister
Journal:  Tetrahedron Lett       Date:  2015-04-08       Impact factor: 2.415

4.  Antifungal and anthelmintic activity of novel benzofuran derivatives containing thiazolo benzimidazole nucleus: an in vitro evaluation.

Authors:  R Kenchappa; Yadav D Bodke; Sandeep Telkar; M Aruna Sindhe
Journal:  J Chem Biol       Date:  2016-09-08

5.  Synthesis and antitumoral activity of novel analogues monastrol-fatty acids against glioma cells.

Authors:  Franciele S De Oliveira; Patrick M De Oliveira; Luana M Farias; Rafael C Brinkerhoff; Rui Carlos M A Sobrinho; Tamara M Treptow; Caroline R Montes D'Oca; Marcelo A G Marinho; Mariana A Hort; Ana P Horn; Dennis Russowsky; Marcelo G Montes D'Oca
Journal:  Medchemcomm       Date:  2018-05-30       Impact factor: 3.597

Review 6.  Research developments in the syntheses, anti-inflammatory activities and structure-activity relationships of pyrimidines.

Authors:  Haroon Ur Rashid; Marco Antonio Utrera Martines; Adriana Pereira Duarte; Juliana Jorge; Shagufta Rasool; Riaz Muhammad; Nasir Ahmad; Muhammad Naveed Umar
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

7.  Structural and theoretical studies of 4-chloro-2-methyl-6-oxo-3,6-dideuteropyrimidin-1-ium chloride (d 6).

Authors:  Ray J Butcher; Andrew P Purdy; Sean A Fischer; Daniel Gunlycke
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-03-19

8.  7-(Benzyl-sulfan-yl)-5-(2-methoxy-phen-yl)-1,3-dimethyl-5,6-dihydro-pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione.

Authors:  Ayoob Bazgir; Fereshteh Faraji
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-06

9.  Antimicrobial evaluation of novel substituted pyrimidinopyrazoles and pyrimidinotriazoles.

Authors:  H S Basavaraja; J E Nagamani; M M J Vijay Kumar; Basavaraj Padmashali
Journal:  J Adv Pharm Technol Res       Date:  2010-04

10.  N'-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies.

Authors:  Pradeep Kumar; Balasubramanian Narasimhan; Kalavathy Ramasamy; Vasudevan Mani; Rakesh Kumar Mishra; Abu Bakar Abdul Majeed; Erik De Clercq
Journal:  Monatsh Chem       Date:  2012-12-01       Impact factor: 1.451
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