Literature DB >> 15259663

Practicability of protontherapy using compact laser systems.

Victor Malka1, Sven Fritzler, Erik Lefebvre, Emmanuel d'Humières, Régis Ferrand, Georges Grillon, Claude Albaret, Samuel Meyroneinc, Jean-Paul Chambaret, Andre Antonetti, Danièle Hulin.   

Abstract

Protontherapy is a well-established approach to treat cancer due to the favorable ballistic properties of proton beams. Nevertheless, this treatment is today only possible with large scale accelerator facilities which are very difficult to install at existing hospitals. In this article we report on a new approach for proton acceleration up to energies within the therapeutic window between 60 and 200 MeV by using modern, high intensity and compact laser systems. By focusing such laser beams onto thin foils we obtained on target intensities of 6 x 10(19) W/cm2, which is sufficient to produce a well-collimated proton beam with an energy of up to 10 MeV. These results are in agreement with numerical simulations and indicate that proton energies within the therapeutic window should be obtained in the very near future using such economical and very compact laser systems. Hence, this approach could revolutionize cancer treatment by bringing the "lab to the hospital-rather than the hospital to the lab".

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Year:  2004        PMID: 15259663     DOI: 10.1118/1.1747751

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  24 in total

1.  A parameter study of pencil beam proton dose distributions for the treatment of ocular melanoma utilizing spot scanning.

Authors:  Kenneth Sutherland; Satoshi Miyajima; Hiroyuki Date; Hiroki Shirato; Masayori Ishikawa; Masao Murakami; Mitsuru Yamagiwa; Paul Bolton; Toshiki Tajima
Journal:  Radiol Phys Technol       Date:  2009-09-19

2.  Generation of GeV protons from 1 PW laser interaction with near critical density targets.

Authors:  Stepan S Bulanov; Valery Yu Bychenkov; Vladimir Chvykov; Galina Kalinchenko; Dale William Litzenberg; Takeshi Matsuoka; Alexander G R Thomas; Louise Willingale; Victor Yanovsky; Karl Krushelnick; Anatoly Maksimchuk
Journal:  Phys Plasmas       Date:  2010-04-12       Impact factor: 2.023

3.  Accelerating protons to therapeutic energies with ultraintense, ultraclean, and ultrashort laser pulses.

Authors:  Stepan S Bulanov; Andrei Brantov; Valery Yu Bychenkov; Vladimir Chvykov; Galina Kalinchenko; Takeshi Matsuoka; Pascal Rousseau; Stephen Reed; Victor Yanovsky; Karl Krushelnick; Dale William Litzenberg; Anatoly Maksimchuk
Journal:  Med Phys       Date:  2008-05       Impact factor: 4.071

4.  Maximum proton kinetic energy and patient-generated neutron fluence considerations in proton beam arc delivery radiation therapy.

Authors:  E Sengbusch; A Pérez-Andújar; P M DeLuca; T R Mackie
Journal:  Med Phys       Date:  2009-02       Impact factor: 4.071

5.  Accelerating monoenergetic protons from ultrathin foils by flat-top laser pulses in the directed-Coulomb-explosion regime.

Authors:  S S Bulanov; A Brantov; V Yu Bychenkov; V Chvykov; G Kalinchenko; T Matsuoka; P Rousseau; S Reed; V Yanovsky; D W Litzenberg; K Krushelnick; A Maksimchuk
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2008-08-22

6.  Survival of tumor cells after proton irradiation with ultra-high dose rates.

Authors:  Susanne Auer; Volker Hable; Christoph Greubel; Guido A Drexler; Thomas E Schmid; Claus Belka; Günther Dollinger; Anna A Friedl
Journal:  Radiat Oncol       Date:  2011-10-18       Impact factor: 3.481

7.  Preferential enhancement of laser-driven carbon ion acceleration from optimized nanostructured surfaces.

Authors:  Malay Dalui; W-M Wang; T Madhu Trivikram; Subhrangsu Sarkar; Sheroy Tata; J Jha; P Ayyub; Z M Sheng; M Krishnamurthy
Journal:  Sci Rep       Date:  2015-07-08       Impact factor: 4.379

8.  Guided post-acceleration of laser-driven ions by a miniature modular structure.

Authors:  Satyabrata Kar; Hamad Ahmed; Rajendra Prasad; Mirela Cerchez; Stephanie Brauckmann; Bastian Aurand; Giada Cantono; Prokopis Hadjisolomou; Ciaran L S Lewis; Andrea Macchi; Gagik Nersisyan; Alexander P L Robinson; Anna M Schroer; Marco Swantusch; Matt Zepf; Oswald Willi; Marco Borghesi
Journal:  Nat Commun       Date:  2016-04-18       Impact factor: 14.919

9.  Maximum kinetic energy considerations in proton stereotactic radiosurgery.

Authors:  Evan R Sengbusch; Thomas R Mackie
Journal:  J Appl Clin Med Phys       Date:  2011-04-12       Impact factor: 2.102

10.  Bacterial cells enhance laser driven ion acceleration.

Authors:  Malay Dalui; M Kundu; T Madhu Trivikram; R Rajeev; Krishanu Ray; M Krishnamurthy
Journal:  Sci Rep       Date:  2014-08-08       Impact factor: 4.379

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