Literature DB >> 15255884

The Walker Project: a longitudinal study of 48,000 children born 1952-1966 (aged 36-50 years in 2002) and their families.

Gillian Libby1, Anne Smith, Neil F McEwan, Patrick F W Chien, Stephen A Greene, J Stewart Forsyth, Iain K Crombie, Thomas M Macdonald, Andrew D Morris.   

Abstract

The Walker cohort is a database of over 48,000 birth records that has recently become available. It contains meticulously recorded details of pregnancy, labour, birth and care before discharge for babies born in hospital in Dundee, Scotland between 1952 and 1966. These babies accounted for 75% of all births in Dundee at this time. Over 34,000 (73%) of these subjects can be identified and this presents the opportunity to link this birth information with a large number of current health-outcome databases covering both primary and secondary care. Further, it allows linkage of records across siblings and over two and, in future, three generations. The number of birth records available and linkage to current databases make this a unique birth cohort with huge potential for the investigation of the fetal origins of adult disease.

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Year:  2004        PMID: 15255884     DOI: 10.1111/j.1365-3016.2004.00575.x

Source DB:  PubMed          Journal:  Paediatr Perinat Epidemiol        ISSN: 0269-5022            Impact factor:   3.980


  8 in total

1.  Pre-eclampsia and the later development of type 2 diabetes in mothers and their children: an intergenerational study from the Walker cohort.

Authors:  G Libby; D J Murphy; N F McEwan; S A Greene; J S Forsyth; P W Chien; A D Morris
Journal:  Diabetologia       Date:  2006-12-23       Impact factor: 10.122

2.  Associations between parental type 2 diabetes risk and offspring birthweight and placental weight: a survival analysis using the Walker cohort.

Authors:  Carlos Sánchez-Soriano; Ewan R Pearson; Rebecca M Reynolds
Journal:  Diabetologia       Date:  2022-08-11       Impact factor: 10.460

3.  Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability.

Authors:  Blair H Smith; Harry Campbell; Douglas Blackwood; John Connell; Mike Connor; Ian J Deary; Anna F Dominiczak; Bridie Fitzpatrick; Ian Ford; Cathy Jackson; Gillian Haddow; Shona Kerr; Robert Lindsay; Mark McGilchrist; Robin Morton; Graeme Murray; Colin N A Palmer; Jill P Pell; Stuart H Ralston; David St Clair; Frank Sullivan; Graham Watt; Roland Wolf; Alan Wright; David Porteous; Andrew D Morris
Journal:  BMC Med Genet       Date:  2006-10-02       Impact factor: 2.103

4.  Generation Scotland participant survey on data collection.

Authors:  Rachel Edwards; Archie Campbell; David Porteous
Journal:  Wellcome Open Res       Date:  2019-07-25

5.  Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments.

Authors:  Alison D Murray; Andrew M McIntosh; Tina Habota; Anca-Larisa Sandu; Gordon D Waiter; Christopher J McNeil; J Douglas Steele; Jennifer A Macfarlane; Heather C Whalley; Ruth Valentine; Dawn Younie; Nichola Crouch; Emma L Hawkins; Yoriko Hirose; Liana Romaniuk; Keith Milburn; Gordon Buchan; Tessa Coupar; Mairi Stirling; Baljit Jagpal; Beverly MacLennan; Lucasz Priba; Mathew A Harris; Jonathan D Hafferty; Mark J Adams; Archie I Campbell; Donald J MacIntyre; Alison Pattie; Lee Murphy; Rebecca M Reynolds; Rebecca Elliot; Ian S Penton-Voak; Marcus R Munafò; Kathryn L Evans; Jonathan R Seckl; Joanna M Wardlaw; Stephen M Lawrie; Christopher S Haley; David J Porteous; Ian J Deary
Journal:  Wellcome Open Res       Date:  2021-07-16

6.  The impact of birthweight on subsequent phenotype of type 2 diabetes in later life.

Authors:  Christian Paulina; Louise A Donnelly; Ewan R Pearson
Journal:  Diabet Med       Date:  2022-01-22       Impact factor: 4.213

7.  Early life predictors of late life cerebral small vessel disease in four prospective cohort studies.

Authors:  Ellen V Backhouse; Susan D Shenkin; Andrew M McIntosh; Mark E Bastin; Heather C Whalley; Maria Valdez Hernandez; Susana Muñoz Maniega; Mathew A Harris; Aleks Stolicyn; Archie Campbell; Douglas Steele; Gordon D Waiter; Anca-Larisa Sandu; Jennifer M J Waymont; Alison D Murray; Simon R Cox; Susanne R de Rooij; Tessa J Roseboom; Joanna M Wardlaw
Journal:  Brain       Date:  2021-12-31       Impact factor: 13.501

8.  Birth weight associations with DNA methylation differences in an adult population.

Authors:  Rebecca A Madden; Daniel L McCartney; Rosie M Walker; Robert F Hillary; Mairead L Bermingham; Konrad Rawlik; Stewart W Morris; Archie Campbell; David J Porteous; Ian J Deary; Kathryn L Evans; Jonathan Hafferty; Andrew M McIntosh; Riccardo E Marioni
Journal:  Epigenetics       Date:  2020-10-20       Impact factor: 4.861

  8 in total

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