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Literature DB >> 15254619

A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis.

M Eugenio Vazquez¹, Deborah M Rothman, Barbara Imperiali.

Abstract

A new 4-(N,N-dimethylamino) phthalimide-based environment-sensitive fluorescent building block for solid phase peptide synthesis, has been synthesized and incorporated into peptides. Peptides incorporating this residue show great potential for biological applications in sensing protein/protein interactions.

Entities: Chemical

Mesh：

Substances：

Year: 2004 PMID： 15254619 DOI： 10.1039/b408001g

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

20 in total

1. Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.

Authors: Matthieu Sainlos; Cezar Tigaret; Christel Poujol; Nelson B Olivier; Lucie Bard; Christelle Breillat; Kevin Thiolon; Daniel Choquet; Barbara Imperiali
Journal: Nat Chem Biol Date: 2010-12-26 Impact factor: 15.040

2. 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

Authors: M Eugenio Vázquez; Juan B Blanco; Severo Salvadori; Claudio Trapella; Roberto Argazzi; Sharon D Bryant; Yunden Jinsmaa; Lawrence H Lazarus; Lucia Negri; Elisa Giannini; Roberta Lattanzi; Mariantonella Colucci; Gianfranco Balboni
Journal: J Med Chem Date: 2006-06-15 Impact factor: 7.446

3. Synthesis and Biological Evaluation of Hapten-Clicked Analogues of The Antigenic Peptide Melan-A/MART-1_26(27L)-35.

Authors: Marion Tarbe; John J Miles; Emily S J Edwards; Kim M Miles; Andrew K Sewell; Brian M Baker; Stéphane Quideau
Journal: ChemMedChem Date: 2020-04-06 Impact factor: 3.466

4. A versatile amino acid analogue of the solvatochromic fluorophore 4-N,N-dimethylamino-1,8-naphthalimide: a powerful tool for the study of dynamic protein interactions.

Authors: Galen Loving; Barbara Imperiali
Journal: J Am Chem Soc Date: 2008-09-23 Impact factor: 15.419

10. A general screening strategy for peptide-based fluorogenic ligands: probes for dynamic studies of PDZ domain-mediated interactions.

Authors: Matthieu Sainlos; Wendy S Iskenderian; Barbara Imperiali
Journal: J Am Chem Soc Date: 2009-05-20 Impact factor: 15.419

A new environment-sensitive fluorescent amino acid for Fmoc-based solid phase peptide synthesis.

1. Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.

2. 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

3. Synthesis and Biological Evaluation of Hapten-Clicked Analogues of The Antigenic Peptide Melan-A/MART-1_26(27L)-35.

4. A versatile amino acid analogue of the solvatochromic fluorophore 4-N,N-dimethylamino-1,8-naphthalimide: a powerful tool for the study of dynamic protein interactions.

Review 5. Fluorescent analogs of biomolecular building blocks: design, properties, and applications.

6. Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell fluorescence imaging.

7. FRET-capture: a sensitive method for the detection of dynamic protein interactions.

Review 8. Monitoring protein interactions and dynamics with solvatochromic fluorophores.

9. 2-(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-ylmeth-yl)isoindoline-1,3-dione.

10. A general screening strategy for peptide-based fluorogenic ligands: probes for dynamic studies of PDZ domain-mediated interactions.