OBJECTIVE: The authors evaluated the efficacy of a new cognitive rehabilitation program on memory and functional performance of mildly impaired Alzheimer disease (AD) patients receiving acholinesterase inhibitor. METHODS:Twenty-five participants in the Cognitive Rehabilitation (CR) condition participated in two 45-minute sessions twice per week for 24 total sessions. CR training included face-name association tasks, object recall training, functional tasks (e.g., making change, paying bills), orientation to time and place, visuo-motor speed of processing, and the use of a memory notebook. Nineteen participants in the Mental Stimulation (MS) condition had equivalent therapist contact and number of sessions, which consisted of interactive computer games involving memory, concentration, and problem-solving skills. RESULTS: Compared with the MS condition, participants in CR demonstrated improved performance on tasks that were similar to those used in training. Gains in recall of face-name associations, orientation, cognitive processing speed, and specific functional tasks were present post-intervention and at a 3-month follow-up. CONCLUSION: A systematic program of cognitive rehabilitation can result in maintained improvement in performance on specific cognitive and functional tasks in mildly impaired AD patients.
RCT Entities:
OBJECTIVE: The authors evaluated the efficacy of a new cognitive rehabilitation program on memory and functional performance of mildly impaired Alzheimer disease (AD) patients receiving a cholinesterase inhibitor. METHODS: Twenty-five participants in the Cognitive Rehabilitation (CR) condition participated in two 45-minute sessions twice per week for 24 total sessions. CR training included face-name association tasks, object recall training, functional tasks (e.g., making change, paying bills), orientation to time and place, visuo-motor speed of processing, and the use of a memory notebook. Nineteen participants in the Mental Stimulation (MS) condition had equivalent therapist contact and number of sessions, which consisted of interactive computer games involving memory, concentration, and problem-solving skills. RESULTS: Compared with the MS condition, participants in CR demonstrated improved performance on tasks that were similar to those used in training. Gains in recall of face-name associations, orientation, cognitive processing speed, and specific functional tasks were present post-intervention and at a 3-month follow-up. CONCLUSION: A systematic program of cognitive rehabilitation can result in maintained improvement in performance on specific cognitive and functional tasks in mildly impaired ADpatients.
Authors: Henry W Mahncke; Bonnie B Connor; Jed Appelman; Omar N Ahsanuddin; Joseph L Hardy; Richard A Wood; Nicholas M Joyce; Tania Boniske; Sharona M Atkins; Michael M Merzenich Journal: Proc Natl Acad Sci U S A Date: 2006-08-03 Impact factor: 11.205
Authors: Jennifer R Cracchiolo; Takashi Mori; Stanley J Nazian; Jun Tan; Huntington Potter; Gary W Arendash Journal: Neurobiol Learn Mem Date: 2007-08-21 Impact factor: 2.877
Authors: Melanie C Greenaway; Sherrie M Hanna; Susan W Lepore; Glenn E Smith Journal: Am J Alzheimers Dis Other Demen Date: 2008 Oct-Nov Impact factor: 2.035
Authors: Cornelia Beck; Jennifer Kleiner Fausett; Rebecca A Krukowski; Carol E Cornell; T Elaine Prewitt; Shelly Lensing; Zoran Bursac; Holly C Felix; ShaRhonda Love; Graham McDougall; Delia Smith West Journal: J Aging Health Date: 2012-12-16