Literature DB >> 1524562

The CEPH YAC library.

J Dausset1, P Ougen, H Abderrahim, A Billault, J L Sambucy, D Cohen, D Le Paslier.   

Abstract

Because of their large size, YACs provide is a powerful tool for physical mapping studies of complex genomes. As it will be advantageous to have genomic libraries of clones with large inserts for analyzing megabase sized regions of the human genome, we have investigated a number of parameters in order to increase the insert size of the YACs. We constructed a genomic library currently containing more than 85,000 YAC clones. Mean sizes of YACs produced at several stages of construction of the library range from 430 kb to 1,200 kb, representing 13 haploid equivalents of the human genome. This library was organized in order to allow rapid screen of YACs for large scale physical mapping of the human genome.

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Year:  1992        PMID： 1524562

Source DB:  PubMed          Journal:  Behring Inst Mitt        ISSN： 0301-0457


  8 in total

1.  A physical map, including a BAC/PAC clone contig, of the Williams-Beuren syndrome--deletion region at 7q11.23.

Authors:  R Peoples; Y Franke; Y K Wang; L Pérez-Jurado; T Paperna; M Cisco; U Francke
Journal:  Am J Hum Genet       Date:  2000-01       Impact factor: 11.025

2.  Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.

Authors:  K A Henning; E A Novotny; S T Compton; X Y Guan; P P Liu; M A Ashlock
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

3.  High-resolution physical mapping by combined Alu-hybridization/PCR screening: construction of a yeast artificial chromosome map covering 31 centimorgans in 3p21-p14.

Authors:  H Aburatani; V P Stanton; D E Housman
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205

4.  Refined genetic mapping of the darier locus to a <1-cM region of chromosome 12q24.1, and construction of a complete, high-resolution P1 artificial chromosome/bacterial artificial chromosome contig of the critical region.

Authors:  S Monk; A Sakuntabhai; S A Carter; S D Bryce; R Cox; L Harrington; E Levy; V L Ruiz-Perez; E Katsantoni; A Kodvawala; C S Munro; S Burge; M Larrègue; G Nagy; J L Rees; M Lathrop; A P Monaco; T Strachan; A Hovnanian
Journal:  Am J Hum Genet       Date:  1998-04       Impact factor: 11.025

5.  Structure of the human aggrecan gene: exon-intron organization and association with the protein domains.

Authors:  W B Valhmu; G D Palmer; P A Rivers; S Ebara; J F Cheng; S Fischer; A Ratcliffe
Journal:  Biochem J       Date:  1995-07-15       Impact factor: 3.857

6.  YAC DNA preparation and labelling for high throughput FISH analysis.

Authors:  D Markie; A Davies
Journal:  Nucleic Acids Res       Date:  1995-02-25       Impact factor: 16.971

7.  Genetic and physical mapping of the progressive epilepsy with mental retardation (EPMR) locus on chromosome 8p.

Authors:  S Ranta; A E Lehesjoki; A Hirvasniemi; J Weissenbach; B Ross; S M Leal; A de la Chapelle; T C Gilliam
Journal:  Genome Res       Date:  1996-05       Impact factor: 9.043

8.  Sites of genetic instability in mitosis and cancer.

Authors:  Anne M Casper; Danielle M Rosen; Kaveri D Rajula
Journal:  Ann N Y Acad Sci       Date:  2012-09       Impact factor: 5.691
  8 in total

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