Literature DB >> 15238064

If the "adaptive" immune system can recognize a significant portion of the pathogenic universe to which the "innate" immune system is blind, then...

M Cohn1.   

Abstract

The "adaptive" immune repertoire functionally recognizes pathogens (and their toxic products) that the "innate" defense system misses. This requires that the self-nonself discrimination and the regulation of effector output be dependent primarily on somatic learning mechanisms (i.e. on the somatically generated, large, random "adaptive" immune paratopes repertoire).

Mesh:

Year:  2004        PMID: 15238064      PMCID: PMC1360149          DOI: 10.1111/j.0300-9475.2004.01449.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN: 0300-9475            Impact factor:   3.487


  4 in total

1.  Decoding the patterns of self and nonself by the innate immune system.

Authors:  Ruslan Medzhitov; Charles A Janeway
Journal:  Science       Date:  2002-04-12       Impact factor: 47.728

Review 2.  Whither T-suppressors: if they didn't exist would we have to invent them?

Authors:  Melvin Cohn
Journal:  Cell Immunol       Date:  2004-02       Impact factor: 4.868

Review 3.  The immune system evolved to discriminate infectious nonself from noninfectious self.

Authors:  C A Janeway
Journal:  Immunol Today       Date:  1992-01

Review 4.  Tolerance, danger, and the extended family.

Authors:  P Matzinger
Journal:  Annu Rev Immunol       Date:  1994       Impact factor: 28.527

  4 in total
  3 in total

Review 1.  Does the signal for the activation of T cells originate from the antigen-presenting cell or the effector T-helper?

Authors:  Melvin Cohn
Journal:  Cell Immunol       Date:  2006-09-11       Impact factor: 4.868

Review 2.  What roles do regulatory T cells play in the control of the adaptive immune response?

Authors:  Melvin Cohn
Journal:  Int Immunol       Date:  2008-07-25       Impact factor: 4.823

3.  On the opposing views of the self-nonself discrimination by the immune system.

Authors:  Melvin Cohn
Journal:  Immunol Cell Biol       Date:  2008-12-02       Impact factor: 5.126

  3 in total

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