Literature DB >> 1523678

An affinity purified ovine antivenom for the treatment of Vipera berus envenoming.

D C Smith1, K R Reddi, G Laing, R G Theakston, J Landon.   

Abstract

A novel antivenom for treating patients with Vipera berus bite has been developed. Sheep are immunised monthly with relatively small amounts of Vipera berus (common adder) venom and the resultant antisera pooled. The immunoglobulin fraction is precipitated with sodium sulphate then cleaved with papain to produce Fab fragments. Finally, those Fab fragments that are directed specifically against components in the venom are purified by affinity chromatography on columns comprising V. berus venom coupled to cyanogen bromide activated Sepharose 4B. The resultant product is some three times more effective than the non-purified Fab in protecting mice against the lethal venom effects.

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Year:  1992        PMID： 1523678     DOI： 10.1016/0041-0101(92)90384-h

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  9 in total

Review 1.  Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation.

Authors:  José María Gutiérrez; Guillermo León; Bruno Lomonte
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

Review 2.  Biochemistry and toxicology of proteins and peptides purified from the venom of Vipera berus berus.

Authors:  Jüri Siigur; Ene Siigur
Journal:  Toxicon X       Date:  2022-06-12

3.  Streamlined downstream process for efficient and sustainable (Fab')2 antivenom preparation.

Authors:  Tihana Kurtović; Marija Brgles; Maja Lang Balija; Stephanie Steinberger; Dora Sviben; Martina Marchetti-Deschmann; Beata Halassy
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2020-07-27

4.  Immunological cross-reactivity and neutralisation of European viper venoms with the monospecific Vipera berus antivenom ViperaTAb.

Authors:  Nicholas R Casewell; Ibrahim Al-Abdulla; David Smith; Ruth Coxon; John Landon
Journal:  Toxins (Basel)       Date:  2014-08-19       Impact factor: 4.546

5.  A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia.

Authors:  Kavi Ratanabanangkoon; Kae Yi Tan; Sukanya Eursakun; Choo Hock Tan; Pavinee Simsiriwong; Teeraporn Pamornsakda; Witthawat Wiriyarat; Chaiya Klinpayom; Nget Hong Tan
Journal:  PLoS Negl Trop Dis       Date:  2016-04-08

6.  Development of a Cost-effective Ovine Polyclonal Antibody-Based Product, EBOTAb, to Treat Ebola Virus Infection.

Authors:  Stuart David Dowall; Jo Callan; Antra Zeltina; Ibrahim Al-Abdulla; Thomas Strecker; Sarah K Fehling; Verena Krähling; Andrew Bosworth; Emma Rayner; Irene Taylor; Sue Charlton; John Landon; Ian Cameron; Roger Hewson; Abdulsalami Nasidi; Thomas A Bowden; Miles W Carroll
Journal:  J Infect Dis       Date:  2015-12-28       Impact factor: 5.226

7.  Refinement strategy for antivenom preparation of high yield and quality.

Authors:  Tihana Kurtović; Maja Lang Balija; Marija Brgles; Dora Sviben; Monika Tunjić; Hrvoje Cajner; Martina Marchetti-Deschmann; Günter Allmaier; Beata Halassy
Journal:  PLoS Negl Trop Dis       Date:  2019-06-17

8.  Vipera berus berus Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom.

Authors:  Ruslan I Al-Shekhadat; Ksenia S Lopushanskaya; Álvaro Segura; José María Gutiérrez; Juan J Calvete; Davinia Pla
Journal:  Toxins (Basel)       Date:  2019-02-01       Impact factor: 4.546

9.  Comparison of Preclinical Properties of Several Available Antivenoms in the Search for Effective Treatment of Vipera ammodytes and Vipera berus Envenoming.

Authors:  Tihana Kurtović; Maja Lang Balija; Miran Brvar; Mojca Dobaja Borak; Sanja Mateljak Lukačević; Beata Halassy
Journal:  Toxins (Basel)       Date:  2021-03-13       Impact factor: 4.546
  9 in total

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