Literature DB >> 15235599

Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.

Lu Chen1, Pedram Hamrah, Claus Cursiefen, Qiang Zhang, Bronislaw Pytowski, J Wayne Streilein, M Reza Dana.   

Abstract

There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.

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Year:  2004        PMID： 15235599     DOI： 10.1038/nm1078

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  102 in total

1.  Live imaging of newly formed lymphatic vessels in the cornea.

Authors:  Don Yuen; Xiufeng Wu; Alex C Kwan; Jeffrey Ledue; Hui Zhang; Tatiana Ecoiffier; Bronislaw Pytowski; Lu Chen
Journal:  Cell Res       Date:  2011-11-15       Impact factor: 25.617

2.  Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis.

Authors:  Simona Schlereth; Hyun Soo Lee; Payal Khandelwal; Daniel R Saban
Journal:  Am J Pathol       Date:  2012-04-14       Impact factor: 4.307

3.  Severing corneal nerves in one eye induces sympathetic loss of immune privilege and promotes rejection of future corneal allografts placed in either eye.

Authors:  K J Paunicka; J Mellon; D Robertson; M Petroll; J R Brown; J Y Niederkorn
Journal:  Am J Transplant       Date:  2015-04-14       Impact factor: 8.086

4.  Vascular endothelial growth factor-C promotes alloimmunity by amplifying antigen-presenting cell maturation and lymphangiogenesis.

Authors:  Amir R Hajrasouliha; Toshinari Funaki; Zahra Sadrai; Takaaki Hattori; Sunil K Chauhan; Reza Dana
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-03-09       Impact factor: 4.799

Review 5.  Graft failure IV. Immunologic mechanisms of corneal transplant rejection.

Authors:  Eva-Marie Chong; M Reza Dana
Journal:  Int Ophthalmol       Date:  2008-06       Impact factor: 2.031

6.  Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision.

Authors:  Claus Cursiefen; Lu Chen; Magali Saint-Geniez; Pedram Hamrah; Yiping Jin; Saadia Rashid; Bronislaw Pytowski; Kris Persaud; Yan Wu; J Wayne Streilein; Reza Dana
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-18       Impact factor: 11.205

7.  Differential distribution of blood and lymphatic vessels in the murine cornea.

Authors:  Tatiana Ecoiffier; Don Yuen; Lu Chen
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-12-17       Impact factor: 4.799

Review 8.  Current and emerging therapies for corneal neovascularization.

Authors:  Danial Roshandel; Medi Eslani; Alireza Baradaran-Rafii; Albert Y Cheung; Khaliq Kurji; Sayena Jabbehdari; Alejandra Maiz; Setareh Jalali; Ali R Djalilian; Edward J Holland
Journal:  Ocul Surf       Date:  2018-06-20       Impact factor: 5.033

9.  Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.

Authors:  Susan N Thomas; Joseph M Rutkowski; Miriella Pasquier; Emma L Kuan; Kari Alitalo; Gwendalyn J Randolph; Melody A Swartz
Journal:  J Immunol       Date:  2012-07-27       Impact factor: 5.422

10.  Soluble vascular endothelial growth factor receptor-3 suppresses allosensitization and promotes corneal allograft survival.

Authors:  Parisa Emami-Naeini; Thomas H Dohlman; Masahiro Omoto; Takaaki Hattori; Yihe Chen; Hyun Soo Lee; Sunil K Chauhan; Reza Dana
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2014-08-05       Impact factor: 3.117
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