| Literature DB >> 17673946 |
Eva-Marie Chong1, M Reza Dana.
Abstract
Corneal transplantation is the oldest and the most common form of solid tissue transplantation in humans. Immunologic graft rejection is one of the main causes of short and long-term graft failure. Rejection involves donor tissue recognition and destruction by allo-specific immune cells of the recipient. This review outlines (1) the immunobiology of transplantation, with reference to ocular immune privilege, (2) factors that confer "high-risk" status to a graft and (3) the pathophysiologic mechanisms of corneal transplant rejection.Entities:
Mesh:
Year: 2008 PMID: 17673946 DOI: 10.1007/s10792-007-9099-9
Source DB: PubMed Journal: Int Ophthalmol ISSN: 0165-5701 Impact factor: 2.031