Literature DB >> 15228256

A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos.

Mayfong Mayxay1, Rattanaxay Phetsouvanh, Samlane Phompida, Paul N Newton, Maniphone Khanthavong, Bouakham Vannachone, Alan Brockmans, Nicholas J White.   

Abstract

Between June and October 2000 we conducted the first randomized trial in Laos comparing chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated Plasmodium falciparum malaria (n = 29, 42-d follow-up, age > 5 years). The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently.

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Year:  2003        PMID： 15228256     DOI： 10.1016/s0035-9203(03)90165-9

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  6 in total

1.  In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up.

Authors:  Kasia Stepniewska; Walter R J Taylor; Mayfong Mayxay; Ric Price; Frank Smithuis; Jean-Paul Guthmann; Karen Barnes; Hla Yin Myint; Martin Adjuik; Piero Olliaro; Sasithon Pukrittayakamee; Sornchai Looareesuwan; Tran Tinh Hien; Jeremy Farrar; François Nosten; Nicholas P J Day; Nicholas J White
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

2.  In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).

Authors:  Mayfong Mayxay; Marion Barends; Alan Brockman; Anchalee Jaidee; Shalini Nair; Dan Sudimack; Tiengkham Pongvongsa; Samlane Phompida; Rattanaxay Phetsouvanh; Tim Anderson; Nicholas J White; Paul N Newton
Journal:  Am J Trop Med Hyg       Date:  2007-02       Impact factor: 2.345

3.  A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.

Authors:  Mayfong Mayxay; Sommay Keomany; Maniphone Khanthavong; Phoutthalavanh Souvannasing; Kasia Stepniewska; Tiengthong Khomthilath; Siamphay Keola; Tiengkham Pongvongsa; Samlane Phompida; David Ubben; Neena Valecha; Nicholas J White; Paul N Newton
Journal:  Am J Trop Med Hyg       Date:  2010-12       Impact factor: 2.345

4.  Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos.

Authors:  Mayfong Mayxay; Maniphone Khanthavong; Odai Chanthongthip; Mallika Imwong; Tiengkham Pongvongsa; Bouasy Hongvanthong; Samalane Phompida; Viengxay Vanisaveth; Nicholas J White; Paul N Newton
Journal:  Malar J       Date:  2012-06-08       Impact factor: 2.979

5.  An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.

Authors:  Neena Valecha; Aung Pyae Phyo; Mayfong Mayxay; Paul N Newton; Srivicha Krudsood; Sommay Keomany; Maniphone Khanthavong; Tiengkham Pongvongsa; Ronnatrai Ruangveerayuth; Chirapong Uthaisil; David Ubben; Stephan Duparc; Antonella Bacchieri; Marco Corsi; Bappanad H K Rao; Prabash C Bhattacharya; Nagesh Dubhashi; Susanta K Ghosh; Vas Dev; Ashwani Kumar; Sasithon Pukrittayakamee; Sasithon Pukittayakamee
Journal:  PLoS One       Date:  2010-07-30       Impact factor: 3.240

6.  Efficacy of Pyrimethamine/Sulfadoxine versus Chloroquine for the Treatment of Uncomplicated Falciparum Malaria in Children Aged Under 5 Years.

Authors:  W Zheng; H Jiang; Z Xiong; Z Jiang; H Chen
Journal:  Iran J Parasitol       Date:  2013-01       Impact factor: 1.012
  6 in total

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