Literature DB >> 15225738

Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.

Gary H Posner1, Kenneth R Crawford, Hong Woon Yang, Mehmet Kahraman, Heung Bae Jeon, Hongbin Li, Jae Kyoo Lee, Byung Chul Suh, Mark A Hatcher, Tanzina Labonte, Aimee Usera, Patrick M Dolan, Thomas W Kensler, Sara Peleg, Glenville Jones, Anqi Zhang, Bozena Korczak, Uttam Saha, Samuel S Chuang.   

Abstract

The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1alpha,25-dihydroxyvitamin D(3), is a potent (IC(50) = 28nM) and highly selective inhibitor of the human 24-hydroxylase enzyme CYP24.

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Year:  2004        PMID： 15225738     DOI： 10.1016/j.jsbmb.2004.03.044

Source DB:  PubMed          Journal:  J Steroid Biochem Mol Biol        ISSN： 0960-0760            Impact factor:   4.292


  7 in total

1.  Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase.

Authors:  Grazia Chiellini; Simona Rapposelli; Jinge Zhu; Ilaria Massarelli; Marilena Saraceno; Anna Maria Bianucci; Lori A Plum; Margaret Clagett-Dame; Hector F DeLuca
Journal:  Steroids       Date:  2011-11-25       Impact factor: 2.668

2.  A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay.

Authors:  Jan H Beumer; Robert A Parise; Beatriz Kanterewicz; Martin Petkovich; David Z D'Argenio; Pamela A Hershberger
Journal:  Steroids       Date:  2012-01-20       Impact factor: 2.668

Review 3.  Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.

Authors:  Slobodan P Rendic; F Peter Guengerich
Journal:  Drug Metab Rev       Date:  2018-08       Impact factor: 4.518

4.  Development of novel Vitamin D Receptor-Coactivator Inhibitors.

Authors:  Preetpal S Sidhu; Nicholas Nassif; Megan M McCallum; Kelly Teske; Belaynesh Feleke; Nina Y Yuan; Premchendar Nandhikonda; James M Cook; Rakesh K Singh; Daniel D Bikle; Leggy A Arnold
Journal:  ACS Med Chem Lett       Date:  2014-02-13       Impact factor: 4.345

5.  Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK pathway.

Authors:  Jing Zhang; Gary H Posner; Michael Danilenko; George P Studzinski
Journal:  J Steroid Biochem Mol Biol       Date:  2007-05-16       Impact factor: 4.292

Review 6.  Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.

Authors:  Robert D Bruno; Vincent C O Njar
Journal:  Bioorg Med Chem       Date:  2007-05-23       Impact factor: 3.641

Review 7.  SNAIL vs vitamin D receptor expression in colon cancer: therapeutics implications.

Authors:  M J Larriba; A Muñoz
Journal:  Br J Cancer       Date:  2005-03-28       Impact factor: 7.640
  7 in total

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