Literature DB >> 15225568

Preclinical testing of three South American antivenoms against the venoms of five medically-important Peruvian snake venoms.

G D Laing1, A Yarleque, A Marcelo, E Rodriguez, D A Warrell, R D G Theakston.   

Abstract

World Health Organization (WHO)-recommended preclinical in vivo and in vitro studies were carried out to compare the efficacy of Brazilian, Peruvian and Colombian antivenoms in neutralizing the venom toxins responsible for the lethal, haemorrhagic, necrotizing, coagulant and defibrinogenating effects of five medically-important Peruvian snake venoms. Overall, the Brazilian antivenom was found to be the most effective followed by the Peruvian and Colombian antivenoms. However, it was concluded that all three antivenoms would be acceptable for use in a randomised clinical trial in envenomed humans in Peru.

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Year:  2004        PMID： 15225568     DOI： 10.1016/j.toxicon.2004.03.020

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  6 in total

1.  Use of a synthetic biosensor for neutralizing activity-biased selection of monoclonal antibodies against atroxlysin-I, an hemorrhagic metalloproteinase from Bothrops atrox snake venom.

Authors:  Francisco Santos Schneider; Dung Le Nguyen; Karen Larissa Castro; Sandra Cobo; Ricardo Andrez Machado de Avila; Nivia de Assis Ferreira; Eladio Flores Sanchez; Christophe Nguyen; Claude Granier; Pascale Galéa; Carlos Chávez-Olortegui; Franck Molina
Journal:  PLoS Negl Trop Dis       Date:  2014-04-24

Review 2.  Diagnosis of snakebite and the importance of immunological tests in venom research.

Authors:  R David G Theakston; Gavin D Laing
Journal:  Toxins (Basel)       Date:  2014-05-23       Impact factor: 4.546

3.  Safety and efficacy of a freeze-dried trivalent antivenom for snakebites in the Brazilian Amazon: An open randomized controlled phase IIb clinical trial.

Authors:  Iran Mendonça-da-Silva; Antônio Magela Tavares; Jacqueline Sachett; José Felipe Sardinha; Lilian Zaparolli; Maria Fátima Gomes Santos; Marcus Lacerda; Wuelton Marcelo Monteiro
Journal:  PLoS Negl Trop Dis       Date:  2017-11-27

4.  Venomics and antivenomics of the poorly studied Brazil's lancehead, Bothrops brazili (Hoge, 1954), from the Brazilian State of Pará.

Authors:  Libia Sanz; Alicia Pérez; Sarai Quesada-Bernat; Rafaela Diniz-Sousa; Leonardo A Calderón; Andreimar M Soares; Juan J Calvete; Cleópatra A S Caldeira
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2020-04-17

5.  Comparative characterization of Viperidae snake venoms from Perú reveals two compositional patterns of phospholipase A2 expression.

Authors:  Bruno Lomonte; Cecilia Díaz; Fernando Chaves; Julián Fernández; Marco Ruiz; María Salas; Alfonso Zavaleta; Juan J Calvete; Mahmood Sasa
Journal:  Toxicon X       Date:  2020-05-30

6.  Immunorecognition and Neutralization of Crotalus durissus cumanensis Venom by a Commercial Antivenom Produced in Colombia.

Authors:  Augusto Acosta-Peña; Vitelbina Núñez; Jaime Andres Pereañez; Paola Rey-Suárez
Journal:  Toxins (Basel)       Date:  2022-03-25       Impact factor: 5.075
  6 in total

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