Literature DB >> 15225546

A defined human system that supports bidirectional mismatch-provoked excision.

Leonid Dzantiev1, Nicoleta Constantin, Jochen Genschel, Ravi R Iyer, Peter M Burgers, Paul Modrich.   

Abstract

Mismatch-provoked excision directed by a strand break located 3' or 5' to the mispair has been reconstituted using purified human proteins. While MutSalpha, EXOI, and RPA are sufficient to support hydrolysis directed by a 5' strand break, 3' directed excision also requires MutLalpha, PCNA, and RFC. EXOI interacts with PCNA. RFC and PCNA suppress EXOI-mediated 5' to 3' hydrolysis when the nick that directs excision is located 3' to the mispair and activate 3' to 5' excision, which is dependent on loaded PCNA and apparently mediated by a cryptic EXOI 3' to 5' hydrolytic function. By contrast, RFC and PCNA have only a limited effect on 5' to 3' excision directed by a 5' strand break.

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Year:  2004        PMID： 15225546     DOI： 10.1016/j.molcel.2004.06.016

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  126 in total

1.  PCNA and MutLα: partners in crime in triplet repeat expansion?

Authors:  Javier Peña-Diaz; Josef Jiricny
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-07       Impact factor: 11.205

2.  PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair.

Authors:  Anna Pluciennik; Leonid Dzantiev; Ravi R Iyer; Nicoleta Constantin; Farid A Kadyrov; Paul Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-16       Impact factor: 11.205

3.  Mismatch repair causes the dynamic release of an essential DNA polymerase from the replication fork.

Authors:  Andrew D Klocko; Jeremy W Schroeder; Brian W Walsh; Justin S Lenhart; Margery L Evans; Lyle A Simmons
Journal:  Mol Microbiol       Date:  2011-09-30       Impact factor: 3.501

4.  Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.

Authors:  Saravanan Kaliyaperumal; Steve M Patrick; Kandace J Williams
Journal:  Mutat Res       Date:  2010-10-28       Impact factor: 2.433

5.  hMRE11 deficiency leads to microsatellite instability and defective DNA mismatch repair.

Authors:  Anthony T Vo; Fengxue Zhu; Xiling Wu; Fenghua Yuan; Yin Gao; Liya Gu; Guo-Min Li; Tai-Hsien Lee; Chengtao Her
Journal:  EMBO Rep       Date:  2005-05       Impact factor: 8.807

6.  Variation in efficiency of DNA mismatch repair at different sites in the yeast genome.

Authors:  Joshua D Hawk; Lela Stefanovic; Jayne C Boyer; Thomas D Petes; Rosann A Farber
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-02       Impact factor: 11.205

7.  Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection, mismatch repair and nonhomologous tail removal.

Authors:  Tamara Goldfarb; Eric Alani
Journal:  Genetics       Date:  2004-10-16       Impact factor: 4.562

8.  DNA polymerase delta, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae.

Authors:  Stephanie E Corrette-Bennett; Claudia Borgeson; Debbie Sommer; Peter M J Burgers; Robert S Lahue
Journal:  Nucleic Acids Res       Date:  2004-12-01       Impact factor: 16.971

9.  Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair.

Authors:  Jochen Genschel; Lyudmila Y Kadyrova; Ravi R Iyer; Basanta K Dahal; Farid A Kadyrov; Paul Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-24       Impact factor: 11.205

10.  Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.

Authors:  Adam S Mastrocola; Christopher D Heinen
Journal:  DNA Repair (Amst)       Date:  2009-12-08
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