| Literature DB >> 15223251 |
Mathula Thangarajh1, Andreia Gomes, Thomas Masterman, Jan Hillert, Peter Hjelmström.
Abstract
The role of B cells and antibodies in the pathogenesis of multiple sclerosis (MS) is controversial. We investigated the expression of B-cell-activating factor of the tumor necrosis factor family (BAFF), a protein indispensable for B-cell survival, and of its three receptors in MS patients and controls. BAFF mRNA levels in monocytes, and BAFF-receptor mRNA in B and T cells, were higher in patients than in healthy controls; yet, BAFF protein levels in cerebrospinal fluid and plasma were similar in patients and headache controls. In addition, each MS disease course was associated with a unique expression pattern for all four molecules.Entities:
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Year: 2004 PMID： 15223251 DOI： 10.1016/j.jneuroim.2004.03.017
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478