BACKGROUND: BAFF (B-cell activating factor of the tumor necrosis factor family) and APRIL (a proliferation-inducing ligand) are two of the major survival factors for B cells. Many studies have shown that BAFF levels were elevated in MS patients. However, whether the levels of CSF BAFF/APRIL increased in NMO patients was still unclear. OBJECTIVE: To measure the CSF BAFF and APRIL concentration of in NMO patients, and explore their relationship with disease activity in NMO. METHODS: CSF BAFF and APRIL was measured by an enzyme-linked immunosorbent assay (ELISA) in NMO (n = 22), MS (n = 18) patients and controls (n = 14). RESULTS: Concentration of BAFF and APRIL in NMO patients were significantly higher than MS and controls. CSF BAFF and APRIL levels in controls were also lower than MS. Both NMO and MS revealed an increased disease disability with increased CSF BAFF. CSF APRIL was associated with EDSS scores in NMO, but not found in MS. CONCLUSIONS: BAFF/APRIL system considered important for aggressive B cells and T-cell responses, and may stimulates B cells and T cell activation in acute relapse of NMO and MS. In NMO patients, CSF BAFF and APRIL may be key factors of B cell immune response and reflect disease severity.
BACKGROUND:BAFF (B-cell activating factor of the tumor necrosis factor family) and APRIL (a proliferation-inducing ligand) are two of the major survival factors for B cells. Many studies have shown that BAFF levels were elevated in MS patients. However, whether the levels of CSF BAFF/APRIL increased in NMOpatients was still unclear. OBJECTIVE: To measure the CSF BAFF and APRIL concentration of in NMOpatients, and explore their relationship with disease activity in NMO. METHODS: CSF BAFF and APRIL was measured by an enzyme-linked immunosorbent assay (ELISA) in NMO (n = 22), MS (n = 18) patients and controls (n = 14). RESULTS: Concentration of BAFF and APRIL in NMOpatients were significantly higher than MS and controls. CSF BAFF and APRIL levels in controls were also lower than MS. Both NMO and MS revealed an increased disease disability with increased CSF BAFF. CSF APRIL was associated with EDSS scores in NMO, but not found in MS. CONCLUSIONS:BAFF/APRIL system considered important for aggressive B cells and T-cell responses, and may stimulates B cells and T cell activation in acute relapse of NMO and MS. In NMOpatients, CSF BAFF and APRIL may be key factors of B cell immune response and reflect disease severity.
Authors: F Piazza; J C DiFrancesco; M L Fusco; D Corti; L Pirovano; B Frigeni; L Mattavelli; S Andreoni; M Frigo; C Ferrarese; G Tredici; G Cavaletti Journal: J Neuroimmunol Date: 2010-02-11 Impact factor: 3.478
Authors: M Krumbholz; H Faber; F Steinmeyer; L-A Hoffmann; T Kümpfel; H Pellkofer; T Derfuss; C Ionescu; M Starck; C Hafner; R Hohlfeld; E Meinl Journal: Brain Date: 2008-05-12 Impact factor: 13.501
Authors: Chris H Polman; Stephen C Reingold; Brenda Banwell; Michel Clanet; Jeffrey A Cohen; Massimo Filippi; Kazuo Fujihara; Eva Havrdova; Michael Hutchinson; Ludwig Kappos; Fred D Lublin; Xavier Montalban; Paul O'Connor; Magnhild Sandberg-Wollheim; Alan J Thompson; Emmanuelle Waubant; Brian Weinshenker; Jerry S Wolinsky Journal: Ann Neurol Date: 2011-02 Impact factor: 10.422