| Literature DB >> 15219274 |
William B Mathews1, Sung-Eun Yoo, Sung-Hou Lee, Ursula Scheffel, Paige A Rauseo, Tamas G Zober, Gerard Gocco, Kathryn Sandberg, Hayden T Ravert, Robert F Dannals, Zsolt Szabo.
Abstract
2-Butyl-5-methoxymethyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-3H-imidazo[4,5-b]pyridine (KR31173) was radiolabeled by coupling a tetrazole-protected hydroxy precursor with [(11)C] methyl iodide and removing the protecting group by acid hydrolysis. In mice, the highest uptake of [(11)C] KR31173 was in the adrenal glands, kidneys, and liver. Tissue to blood ratios were generally greater than 10:1. Uptake of the tracer in the adrenal glands, kidneys, lungs, and heart was blocked with a 1 mg/kg dose of KR31173 or MK-996.Entities:
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Year: 2004 PMID： 15219274 DOI： 10.1016/j.nucmedbio.2003.10.014
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408