Literature DB >> 15215345

3DCoffee@igs: a web server for combining sequences and structures into a multiple sequence alignment.

Olivier Poirot1, Karsten Suhre, Chantal Abergel, Eamonn O'Toole, Cedric Notredame.   

Abstract

This paper presents 3DCoffee@igs, a web-based tool dedicated to the computation of high-quality multiple sequence alignments (MSAs). 3D-Coffee makes it possible to mix protein sequences and structures in order to increase the accuracy of the alignments. Structures can be either provided as PDB identifiers or directly uploaded into the server. Given a set of sequences and structures, pairs of structures are aligned with SAP while sequence-structure pairs are aligned with Fugue. The resulting collection of pairwise alignments is then combined into an MSA with the T-Coffee algorithm. The server and its documentation are available from http://igs-server.cnrs-mrs.fr/Tcoffee/.

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Year:  2004        PMID: 15215345      PMCID: PMC441520          DOI: 10.1093/nar/gkh382

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN: 0305-1048            Impact factor:   16.971


  17 in total

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