Literature DB >> 15215146

Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.

Thomas W North1, Getachew Sequar, Leroy B Townsend, John C Drach, Peter A Barry.   

Abstract

Rhesus and human cytomegalovirus (RhCMV and HCMV, respectively) exhibit comparable inhibition by benzimidazole nucleosides, including 2,5,6-trichloro-(1-beta-d-ribofuranosyl)benzimidazole (TCRB), and pyrrolo[2,3-d]pyrimidines. The two HCMV protein targets of TCRB, UL89 and UL56, are highly conserved with their RhCMV homologues. These data indicate that infection of rhesus macaques with RhCMV represents a useful model to test novel anti-HCMV drugs.

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Year:  2004        PMID： 15215146      PMCID： PMC434194          DOI： 10.1128/AAC.48.7.2760-2765.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  41 in total

1.  Disseminated cytomegalovirus infection in immunodeficient rhesus monkeys.

Authors:  G B Baskin
Journal:  Am J Pathol       Date:  1987-11       Impact factor: 4.307

2.  Structure and variability of the a sequence in the genome of human cytomegalovirus (Towne strain).

Authors:  E S Mocarski; A C Liu; R R Spaete
Journal:  J Gen Virol       Date:  1987-08       Impact factor: 3.891

3.  Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles.

Authors:  M T Migawa; J L Girardet; J A Walker; G W Koszalka; S D Chamberlain; J C Drach; L B Townsend
Journal:  J Med Chem       Date:  1998-04-09       Impact factor: 7.446

4.  Cytotoxic T-lymphocyte responses to cytomegalovirus in normal and simian immunodeficiency virus-infected rhesus macaques.

Authors:  A Kaur; M D Daniel; D Hempel; D Lee-Parritz; M S Hirsch; R P Johnson
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

5.  Experimental congenital disease with simian cytomegalovirus in rhesus monkeys.

Authors:  W T London; A J Martinez; S A Houff; W C Wallen; B L Curfman; R G Traub; J L Sever
Journal:  Teratology       Date:  1986-06

6.  Cloning and characterization of rhesus cytomegalovirus glycoprotein B.

Authors:  R H Kravitz; K S Sciabica; K Cho; P A Luciw; P A Barry
Journal:  J Gen Virol       Date:  1997-08       Impact factor: 3.891

7.  Differential detection of B virus and rhesus cytomegalovirus in rhesus macaques.

Authors:  J L Huff; R Eberle; J Capitanio; S S Zhou; P A Barry
Journal:  J Gen Virol       Date:  2003-01       Impact factor: 3.891

8.  Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients.

Authors:  A Sarasini; F Baldanti; M Furione; E Percivalle; R Brerra; M Barbi; G Gerna
Journal:  J Med Virol       Date:  1995-11       Impact factor: 2.327

9.  Replication of rhesus cytomegalovirus in life-expanded rhesus fibroblasts expressing human telomerase.

Authors:  W L William Chang; Veronica Kirchoff; Gregory S Pari; Peter A Barry
Journal:  J Virol Methods       Date:  2002-07       Impact factor: 2.014

10.  Resistance of human cytomegalovirus to benzimidazole ribonucleosides maps to two open reading frames: UL89 and UL56.

Authors:  P M Krosky; M R Underwood; S R Turk; K W Feng; R K Jain; R G Ptak; A C Westerman; K K Biron; L B Townsend; J C Drach
Journal:  J Virol       Date:  1998-06       Impact factor: 5.103
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  4 in total

1.  Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.

Authors:  Marta Nadal; Philippe J Mas; Phillipe J Mas; Alexandre G Blanco; Carme Arnan; Maria Solà; Darren J Hart; Miquel Coll
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-30       Impact factor: 11.205

Review 2.  Cytomegalovirus antivirals and development of improved animal models.

Authors:  Alistair McGregor; K Yeon Choi
Journal:  Expert Opin Drug Metab Toxicol       Date:  2011-09-01       Impact factor: 4.481

3.  Immunogenicity and protective efficacy of DNA vaccines expressing rhesus cytomegalovirus glycoprotein B, phosphoprotein 65-2, and viral interleukin-10 in rhesus macaques.

Authors:  Yujuan Yue; Amitinder Kaur; Meghan K Eberhardt; Nadine Kassis; Shan Shan Zhou; Alice F Tarantal; Peter A Barry
Journal:  J Virol       Date:  2006-11-15       Impact factor: 5.103

Review 4.  Rhesus CMV: an emerging animal model for human CMV.

Authors:  Colin Powers; Klaus Früh
Journal:  Med Microbiol Immunol       Date:  2008-01-11       Impact factor: 3.402
  4 in total

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