| Literature DB >> 15214797 |
Suzanne B Buck1, Jacquelyn K Huff, Richard H Himes, Gunda I Georg.
Abstract
Epi-C3-cryptophycin-24, epi-C3-m-chlorobenzyl-cryptophycin-24, and the corresponding styrenes were synthesized and tested in vitro against the MCF-7 and multidrug-resistant MCF-7/ADR breast cancer cell lines and in an in vitro tubulin assembly assay. The results demonstrate that the S configuration at the C3 stereocenter is not required to induce potent cytotoxicity and the m-Cl substituent present on the C10 side chain did not induce any large change in activity.Entities:
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Year: 2004 PMID： 15214797 DOI： 10.1021/jm030555f
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446