| Literature DB >> 15214788 |
Elena A Shirokova1, Maxim V Jasko, Anastasiya L Khandazhinskaya, Alexander V Ivanov, Dmitry V Yanvarev, Yury S Skoblov, Vladimir A Mitkevich, Eduard V Bocharov, Tatyana R Pronyaeva, Nina V Fedyuk, Marina K Kukhanova, Andrey G Pokrovsky.
Abstract
Two series of new lipophilic phosphonoformate and phosphonoacetate derivatives of AZT and d4T were synthesized and evaluated as anti-HIV agents. The efficacy of some of the synthesized compounds in cell cultures infected with HIV-1 was higher than that of the parent nucleosides and only slightly correlated to their stability in the phosphate buffer and human blood serum. The synthesized phosphonates are most probably prodrug forms of the corresponding nucleosides.Entities:
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Year: 2004 PMID： 15214788 DOI： 10.1021/jm0310176
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446