Literature DB >> 15214773

Fragment-based drug discovery.

Daniel A Erlanson1, Robert S McDowell, Tom O'Brien.   

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Year:  2004        PMID： 15214773     DOI： 10.1021/jm040031v

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  105 in total

1.  Hot spot analysis for driving the development of hits into leads in fragment-based drug discovery.

Authors:  David R Hall; Chi Ho Ngan; Brandon S Zerbe; Dima Kozakov; Sandor Vajda
Journal:  J Chem Inf Model       Date:  2011-12-15       Impact factor: 4.956

2.  Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

Authors:  Lujia Zhou; Lucia Chávez-Gutiérrez; Katrijn Bockstael; Ragna Sannerud; Wim Annaert; Patrick C May; Eric Karran; Bart De Strooper
Journal:  J Biol Chem       Date:  2011-01-05       Impact factor: 5.157

3.  Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces.

Authors:  Brandon S Zerbe; David R Hall; Sandor Vajda; Adrian Whitty; Dima Kozakov
Journal:  J Chem Inf Model       Date:  2012-07-24       Impact factor: 4.956

4.  Screening a fragment cocktail library using ultrafiltration.

Authors:  Sayaka Shibata; Zhongsheng Zhang; Konstantin V Korotkov; Jaclyn Delarosa; Alberto Napuli; Angela M Kelley; Natasha Mueller; Jennifer Ross; Frank H Zucker; Frederick S Buckner; Ethan A Merritt; Christophe L M J Verlinde; Wesley C Van Voorhis; Wim G J Hol; Erkang Fan
Journal:  Anal Bioanal Chem       Date:  2011-07-13       Impact factor: 4.142

Review 5.  Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

Authors:  Tom L Blundell; Bancinyane L Sibanda; Rinaldo Wander Montalvão; Suzanne Brewerton; Vijayalakshmi Chelliah; Catherine L Worth; Nicholas J Harmer; Owen Davies; David Burke
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-03-29       Impact factor: 6.237

6.  Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4.

Authors:  Erik Evensen; Diane Joseph-McCarthy; Gregory A Weiss; Stuart L Schreiber; Martin Karplus
Journal:  J Comput Aided Mol Des       Date:  2007-07-27       Impact factor: 3.686

7.  Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.

Authors:  Kerim Babaoglu; Anton Simeonov; John J Irwin; Michael E Nelson; Brian Feng; Craig J Thomas; Laura Cancian; M Paola Costi; David A Maltby; Ajit Jadhav; James Inglese; Christopher P Austin; Brian K Shoichet
Journal:  J Med Chem       Date:  2008-03-12       Impact factor: 7.446

8.  Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation.

Authors:  Kathryn Loving; Noeris K Salam; Woody Sherman
Journal:  J Comput Aided Mol Des       Date:  2009-05-07       Impact factor: 3.686

9.  Design of compound libraries for fragment screening.

Authors:  Niklas Blomberg; David A Cosgrove; Peter W Kenny; Karin Kolmodin
Journal:  J Comput Aided Mol Des       Date:  2009-03-13       Impact factor: 3.686

Review 10.  Perspectives on NMR in drug discovery: a technique comes of age.

Authors:  Maurizio Pellecchia; Ivano Bertini; David Cowburn; Claudio Dalvit; Ernest Giralt; Wolfgang Jahnke; Thomas L James; Steve W Homans; Horst Kessler; Claudio Luchinat; Bernd Meyer; Hartmut Oschkinat; Jeff Peng; Harald Schwalbe; Gregg Siegal
Journal:  Nat Rev Drug Discov       Date:  2008-09       Impact factor: 84.694
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