Literature DB >> 15214481

Esmodil: an acetylcholine mimetic resurfaces in a Southern Australian marine sponge Raspailia (Raspailia) sp.

Robert J Capon1, Colin Skene, Edward H Liu, Ernest Lacey, Jennifer H Gill, Kirstin Heiland, Thomas Friedel.   

Abstract

Bioassay directed fractionation of a Raspailia (Raspailia) sp. (Order Poecilosclerida; Family Raspailiidae) collected during scientific trawling operations off the Northern Rottnest Shelf yielded as nematocidal agents the known metabolites, phorboxazoles A (1) and B (2). Further examination revealed the new natural product but known synthetic compound, esmodil (3). The structure for 3 was confirmed by spectroscopic analysis and total synthesis.

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Year:  2004        PMID: 15214481     DOI: 10.1080/14786410310001620619

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN: 1478-6419            Impact factor:   2.861


  5 in total

1.  Assembly of the isoindolinone core of muironolide A by asymmetric intramolecular Diels-Alder cycloaddition.

Authors:  Beatris Flores; Tadeusz F Molinski
Journal:  Org Lett       Date:  2011-07-13       Impact factor: 6.005

Review 2.  Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Roberto G S Berlinck; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2007-02-09       Impact factor: 3.228

Review 3.  Microscale methodology for structure elucidation of natural products.

Authors:  Tadeusz F Molinski
Journal:  Curr Opin Biotechnol       Date:  2010-09-27       Impact factor: 9.740

Review 4.  Synthesis of the phorboxazoles-potent, architecturally novel marine natural products.

Authors:  Zachary Shultz; James W Leahy
Journal:  J Antibiot (Tokyo)       Date:  2016-03-09       Impact factor: 2.649

5.  Natural products isolated from species of Halgerda bergh, 1880 (Mollusca: Nudibranchia) and their ecological and evolutionary implications.

Authors:  Shireen J Fahey; Anthony R Carroll
Journal:  J Chem Ecol       Date:  2007-04-25       Impact factor: 2.793

  5 in total

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