Literature DB >> 15213185

Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils.

Riana Cockeran1, Annette J Theron, Charles Feldman, Timothy J Mitchell, Ronald Anderson.   

Abstract

Pneumolysin (4.18 ng/ml)-mediated influx of Ca(2+) and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.

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Year:  2004        PMID： 15213185      PMCID： PMC427396          DOI： 10.1128/IAI.72.7.4327-4329.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  16 in total

1.  Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells.

Authors:  M Hashimoto; S Hossain; H Yamasaki; K Yazawa; S Masumura
Journal:  Lipids       Date:  1999-12       Impact factor: 1.880

2.  Biological activities and pore formation of Clostridium perfringens beta toxin in HL 60 cells.

Authors:  Masahiro Nagahama; Shinya Hayashi; Shinsuke Morimitsu; Jun Sakurai
Journal:  J Biol Chem       Date:  2003-07-08       Impact factor: 5.157

3.  Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity.

Authors:  F K Saunders; T J Mitchell; J A Walker; P W Andrew; G J Boulnois
Journal:  Infect Immun       Date:  1989-08       Impact factor: 3.441

4.  Activity of the leukocyte NADPH oxidase in whole neutrophils and cell-free neutrophil preparations stimulated with long-chain polyunsaturated fatty acids.

Authors:  S M Schneider; V S Fung; J Palmblad; B M Babior
Journal:  Inflammation       Date:  2001-02       Impact factor: 4.092

5.  Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages.

Authors:  J S Braun; R Novak; G Gao; P J Murray; J L Shenep
Journal:  Infect Immun       Date:  1999-08       Impact factor: 3.441

6.  Proinflammatory interactions of pneumolysin with human neutrophils.

Authors:  R Cockeran; A J Theron; H C Steel; N M Matlola; T J Mitchell; C Feldman; R Anderson
Journal:  J Infect Dis       Date:  2001-01-17       Impact factor: 5.226

7.  Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils.

Authors:  Dongmin Shao; Anthony W Segal; Lodewijk V Dekker
Journal:  FEBS Lett       Date:  2003-08-28       Impact factor: 4.124

8.  Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin.

Authors:  Rania Jounblat; Aras Kadioglu; Tim J Mitchell; Peter W Andrew
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

9.  Pneumolysin-dependent and -independent gene expression identified by cDNA microarray analysis of THP-1 human mononuclear cells stimulated by Streptococcus pneumoniae.

Authors:  P David Rogers; Justin Thornton; Katherine S Barker; D Olga McDaniel; Gordon S Sacks; Edwin Swiatlo; Larry S McDaniel
Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

10.  Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro.

Authors:  Riana Cockeran; Chrisna Durandt; Charles Feldman; Timothy J Mitchell; Ronald Anderson
Journal:  J Infect Dis       Date:  2002-07-24       Impact factor: 5.226
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  2 in total

1.  Pneumolysin-mediated activation of NFkappaB in human neutrophils is antagonized by docosahexaenoic acid.

Authors:  H Fickl; R Cockeran; H C Steel; C Feldman; G Cowan; T J Mitchell; R Anderson
Journal:  Clin Exp Immunol       Date:  2005-05       Impact factor: 4.330

2.  Effect of polyunsaturated fatty acids on the reactive oxygen and nitrogen species production by raw 264.7 macrophages.

Authors:  Gabriela Ambrozova; Michaela Pekarova; Antonin Lojek
Journal:  Eur J Nutr       Date:  2009-09-26       Impact factor: 5.614
  2 in total

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