Literature DB >> 12935894

Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils.

Dongmin Shao1, Anthony W Segal, Lodewijk V Dekker.   

Abstract

We have investigated the contribution of lipid rafts to activation of the NADPH oxidase enzyme system in neutrophils. Membrane-bound NADPH oxidase subunits are present in the lipid raft compartment of neutrophils. Cytosolic NADPH oxidase components are mainly absent from but are recruited to rafts upon Fcgamma receptor activation. In parallel, protein kinase C isotypes are recruited to the rafts. Kinetic analysis of NADPH oxidase activation revealed that rafts determine the onset but not the maximal rate of enzyme activity. Thus lipid rafts serve to physically juxtapose the NADPH oxidase effector, protein kinase C and Fcgamma receptor, resulting in efficient coupling.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12935894     DOI： 10.1016/s0014-5793(03)00845-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  47 in total

1.  The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly.

Authors:  Frederik Vilhardt; Bo van Deurs
Journal:  EMBO J       Date:  2004-02-05       Impact factor: 11.598

2.  Recruitment of the cross-linked opsonic receptor CD32A (FcgammaRIIA) to high-density detergent-resistant membrane domains in human neutrophils.

Authors:  Emmanuelle Rollet-Labelle; Sébastien Marois; Kathy Barbeau; Stephen E Malawista; Paul H Naccache
Journal:  Biochem J       Date:  2004-08-01       Impact factor: 3.857

3.  MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis.

Authors:  Carl F Fortin; Anjum Sohail; Qing Sun; Patrick P McDonald; Rafael Fridman; Tamàs Fülöp
Journal:  Int Immunol       Date:  2010-05-25       Impact factor: 4.823

4.  NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.

Authors:  Sung Yong Eum; Ibolya Andras; Bernhard Hennig; Michal Toborek
Journal:  Toxicol Appl Pharmacol       Date:  2009-07-24       Impact factor: 4.219

Review 5.  Signaling components of redox active endosomes: the redoxosomes.

Authors:  Fredrick D Oakley; Duane Abbott; Qiang Li; John F Engelhardt
Journal:  Antioxid Redox Signal       Date:  2009-06       Impact factor: 8.401

Review 6.  Fc receptors and their role in immune regulation and autoimmunity.

Authors:  Toshiyuki Takai
Journal:  J Clin Immunol       Date:  2005-01       Impact factor: 8.317

7.  Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts.

Authors:  Adrien Rossary; Khelifa Arab; Jean-Paul Steghens
Journal:  Biochem J       Date:  2007-08-15       Impact factor: 3.857

8.  Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.

Authors:  Antonio Valencia; Ellen Sapp; Jeffrey S Kimm; Hollis McClory; Patrick B Reeves; Jonathan Alexander; Kwadwo A Ansong; Nicholas Masso; Matthew P Frosch; Kimberly B Kegel; Xueyi Li; Marian DiFiglia
Journal:  Hum Mol Genet       Date:  2012-12-07       Impact factor: 6.150

Review 9.  Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins.

Authors:  Srikanth Pendyala; Peter V Usatyuk; Irina A Gorshkova; Joe G N Garcia; Viswanathan Natarajan
Journal:  Antioxid Redox Signal       Date:  2009-04       Impact factor: 8.401

10.  The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V.

Authors:  Adrien F Vinet; Mitsunori Fukuda; Salvatore J Turco; Albert Descoteaux
Journal:  PLoS Pathog       Date:  2009-10-16       Impact factor: 6.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.