Literature DB >> 15213175

Multivariate analysis of cytokine responses identifies distinctive sensitivities to lipopolysaccharide in humans.

David D Duncan1, Lorrie Tiberio, John H Eldridge.   

Abstract

We describe methods to identify high and low responders in a whole-blood assay of lipopolysaccharide-stimulated cytokine responses. Two multivariate measures of the cytokine responses both captured high and low responses for each of the four individual cytokines that were assayed.

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Year:  2004        PMID： 15213175      PMCID： PMC427430          DOI： 10.1128/IAI.72.7.4282-4285.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  26 in total

1.  Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus.

Authors:  A W Gibson; J C Edberg; J Wu; R G Westendorp; T W Huizinga; R P Kimberly
Journal:  J Immunol       Date:  2001-03-15       Impact factor: 5.422

2.  TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.

Authors:  N C Arbour; E Lorenz; B C Schutte; J Zabner; J N Kline; M Jones; K Frees; J L Watt; D A Schwartz
Journal:  Nat Genet       Date:  2000-06       Impact factor: 38.330

3.  Sex differences in posttraumatic cytokine release of endotoxin-stimulated whole blood: relationship to the development of severe sepsis.

Authors:  M Majetschak; B Christensen; U Obertacke; C Waydhas; A E Schindler; D Nast-Kolb; F U Schade
Journal:  J Trauma       Date:  2000-05

4.  Gender differences in cytokine secretion by human peripheral blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model.

Authors:  K Asai; N Hiki; Y Mimura; T Ogawa; K Unou; M Kaminishi
Journal:  Shock       Date:  2001-11       Impact factor: 3.454

Review 5.  Sepsis: a pro- and anti-inflammatory disequilibrium syndrome.

Authors:  M R Pinsky
Journal:  Contrib Nephrol       Date:  2001       Impact factor: 1.580

6.  Can the interleukin-6 response to endotoxin be predicted? Studies of the influence of a promoter polymorphism of the interleukin-6 gene, gender, the density of the endotoxin receptor CD14, and inflammatory cytokines.

Authors:  Michael Heesen; Brunhilde Bloemeke; Nicole Heussen; Dagmar Kunz
Journal:  Crit Care Med       Date:  2002-03       Impact factor: 7.598

7.  Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome.

Authors:  M W Wichmann; D Inthorn; H J Andress; F W Schildberg
Journal:  Intensive Care Med       Date:  2000-02       Impact factor: 17.440

8.  Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families.

Authors:  J Hull; A Thomson; D Kwiatkowski
Journal:  Thorax       Date:  2000-12       Impact factor: 9.139

9.  Influence of TNFalpha gene polymorphisms on TNFalpha production and disease.

Authors:  A H Hajeer; I V Hutchinson
Journal:  Hum Immunol       Date:  2001-11       Impact factor: 2.850

Review 10.  Immunotherapy of sepsis.

Authors:  T van der Poll
Journal:  Lancet Infect Dis       Date:  2001-10       Impact factor: 25.071
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