Literature DB >> 15210162

Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dog.

G Diane Shelton1, Veronique Sammut, Saschiko Homma, Shinichi Takayama, Andrew P Mizisin.   

Abstract

A 1-year-old male neutered Australian Shepherd dog was referred to a veterinary specialist for evaluation of chronic lameness, contractures, and exercise intolerance. Serum creatine kinase was elevated, and electromyography showed complex repetitive discharges. Cardiomyopathy was clinically identified. Muscle biopsies evaluated by light and electron microscopy, and immunohistochemistry revealed the presence of a myofibrillar myopathy with accumulation of desmin and other proteins. These observations represent the first report of myofibrillar myopathy in the dog.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15210162     DOI： 10.1016/j.nmd.2004.03.010

Source DB:  PubMed          Journal:  Neuromuscul Disord        ISSN： 0960-8966            Impact factor:   4.296


  4 in total

1.  BAG3 deficiency results in fulminant myopathy and early lethality.

Authors:  Sachiko Homma; Masahiro Iwasaki; G Diane Shelton; Eva Engvall; John C Reed; Shinichi Takayama
Journal:  Am J Pathol       Date:  2006-09       Impact factor: 4.307

2.  Suspected myofibrillar myopathy in Arabian horses with a history of exertional rhabdomyolysis.

Authors:  S J Valberg; E C McKenzie; L V Eyrich; J Shivers; N E Barnes; C J Finno
Journal:  Equine Vet J       Date:  2015-09-07       Impact factor: 2.888

3.  BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity.

Authors:  Akinori Hishiya; Mortada Najem Salman; Serena Carra; Harm H Kampinga; Shinichi Takayama
Journal:  PLoS One       Date:  2011-03-15       Impact factor: 3.240

4.  Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy.

Authors:  Zoë J Williams; Deborah Velez-Irizarry; Keri Gardner; Stephanie J Valberg
Journal:  BMC Genomics       Date:  2021-06-11       Impact factor: 3.969
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.