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Literature DB >> 1520635

The screening for common drugs of abuse in whole blood by means of EMIT-ETS and FPIA-ADx urine immunoassays.

R D Maier¹, M Erkens, H Hoenen, M Bogusz.

Abstract

The purpose of the paper was to compare the performance of ETS (EMIT) and ADx (FPIA) analyzers for screening blood samples for drugs of abuse after 2 alternative pretreatment procedures (acetone precipitation and ultrafiltration). Cannabinoids, benzodiazepines and benzoylecgonine were not detectable with both assays after ultrafiltration. The detectability of morphine in blood ultrafiltrates was distinctly lower than after acetone precipitation. The comparison of results obtained with ETS and ADx after acetone precipitation showed that ETS assay is slightly more sensitive but ADx is slightly more reproducible. Both assays may be used for blood examination with similar cut-off values. The ETS analyzer gave much better analytical performance (speed, flexibility) and lower reagent costs than the ADx analyzer.

Entities: Chemical

Mesh：

Substances：
Acetone

Year: 1992 PMID： 1520635 DOI： 10.1007/bf02340835

Source DB: PubMed Journal: Int J Legal Med ISSN： 0937-9827 Impact factor: 2.686

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References

18 in total

10. Direct automated EMIT d.a.u. analysis of N,N-dimethylformamide-modified serum, plasma, and postmortem blood for benzodiazepines, benzoylecgonine, cannabinoids, and opiates.

Authors: L M Blum; R A Klinger; F Rieders
Journal: J Anal Toxicol Date: 1989 Sep-Oct Impact factor: 3.367

The screening for common drugs of abuse in whole blood by means of EMIT-ETS and FPIA-ADx urine immunoassays.

1. The analysis of drugs in blood, bile, and tissue with an indirect homogeneous enzyme immunoassay.

2. Inappropriate use of immunoassays as a quantitative tool.

3. Application of the Abbott TDx lidocaine, phenytoin, and phenobarbital assays to postmortem blood specimens.

4. Preliminary evaluation of the Abbott TDx for benzoylecgonine and opiate screening in whole blood.

5. Evaluation of the ETS and ADx urine drug screening immunoassay analyzers.

6. [Cannabis and alcohol in traffic].

7. "Homogeneous" enzyme immunoassay. A new immunochemical technique.

8. Direct and indirect homogeneous enzyme immunoassay of benzodiazepines in biological fluids and tissues.

9. Fluorescence polarization immunoassay for the determination of therapeutic drug levels in human plasma.

10. Direct automated EMIT d.a.u. analysis of N,N-dimethylformamide-modified serum, plasma, and postmortem blood for benzodiazepines, benzoylecgonine, cannabinoids, and opiates.