| Literature DB >> 15203171 |
U Sharma1, J C Marquis, A Nicole Dinaut, S M Hillier, B Fedeles, P T Rye, J M Essigmann, R G Croy.
Abstract
A series of bifunctional compounds was prepared consisting of 17beta estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to the estrogen receptor. Linker characteristics were pivotal determinants underlying the ability of the compounds to kill selectively breast cancer cells that express the estrogen receptor.Entities:
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Year: 2004 PMID： 15203171 PMCID： PMC4096836 DOI： 10.1016/j.bmcl.2004.04.064
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823