Literature DB >> 11990855

DNA and its associated processes as targets for cancer therapy.

Laurence H Hurley1.   

Abstract

DNA is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. Although this is true for traditional chemotherapeutics, other agents that were discovered more recently have shown enhanced efficacy. Furthermore, a new generation of agents that target DNA-associated processes are anticipated to be far more specific and effective. How have these agents evolved, and what are their molecular targets?

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Year:  2002        PMID： 11990855     DOI： 10.1038/nrc749

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  272 in total

1.  Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells.

Authors:  Rosemary A Ndolo; Damon T Jacobs; M Laird Forrest; Jeffrey P Krise
Journal:  Mol Cell Pharmacol       Date:  2010

2.  Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.

Authors:  Liming Ying; Jeremy J Green; Haitao Li; David Klenerman; Shankar Balasubramanian
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-25       Impact factor: 11.205

3.  Groove-binding unsymmetrical cyanine dyes for staining of DNA: syntheses and characterization of the DNA-binding.

Authors:  H Jonas Karlsson; Maja Eriksson; Erik Perzon; Björn Akerman; Per Lincoln; Gunnar Westman
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

4.  Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics.

Authors:  Anh Tuân Phan; Dinshaw J Patel
Journal:  J Am Chem Soc       Date:  2003-12-10       Impact factor: 15.419

5.  Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.

Authors:  Adam Siddiqui-Jain; Cory L Grand; David J Bearss; Laurence H Hurley
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-23       Impact factor: 11.205

6.  Controlling nucleic acid secondary structure by intercalation: effects of DNA strand length on coralyne-driven duplex disproportionation.

Authors:  Swapan S Jain; Matjaz Polak; Nicholas V Hud
Journal:  Nucleic Acids Res       Date:  2003-08-01       Impact factor: 16.971

7.  Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents.

Authors:  U Sharma; J C Marquis; A Nicole Dinaut; S M Hillier; B Fedeles; P T Rye; J M Essigmann; R G Croy
Journal:  Bioorg Med Chem Lett       Date:  2004-07-16       Impact factor: 2.823

8.  Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solution.

Authors:  Anh Tuân Phan; Yasha S Modi; Dinshaw J Patel
Journal:  J Mol Biol       Date:  2004-04-16       Impact factor: 5.469

9.  Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G.

Authors:  Alice Sosic; Ivonne Zuravka; Nina-Katharina Schmitt; Angelica Miola; Richard Göttlich; Dan Fabris; Barbara Gatto
Journal:  ChemMedChem       Date:  2017-08-10       Impact factor: 3.466

10.  Differential Induction of Cytoplasmic Vacuolization and Methuosis by Novel 2-Indolyl-Substituted Pyridinylpropenones.

Authors:  Christopher J Trabbic; Heather M Dietsch; Evan M Alexander; Peter I Nagy; Michael W Robinson; Jean H Overmeyer; William A Maltese; Paul W Erhardt
Journal:  ACS Med Chem Lett       Date:  2014-01-09       Impact factor: 4.345
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