Literature DB >> 15203137

Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase.

Rajendra P Jain1, John C Vederas.   

Abstract

A series of keto-glutamine tetrapeptide analogs containing a 2-oxo-pyrrolidine ring as a glutamine side chain mimic were synthesized with both R and S configuration at the beta-carbon. Compounds bearing a phthalhydrazide moiety show improved reversible inhibition of HAV 3C proteinase in the low micromolar range.

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Year:  2004        PMID： 15203137     DOI： 10.1016/j.bmcl.2004.05.021

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation.

Authors:  Arun K Ghosh; Jun Takayama; Kalapala Venkateswara Rao; Kiira Ratia; Rima Chaudhuri; Debbie C Mulhearn; Hyun Lee; Daniel B Nichols; Surendranath Baliji; Susan C Baker; Michael E Johnson; Andrew D Mesecar
Journal:  J Med Chem       Date:  2010-07-08       Impact factor: 7.446

2.  One-pot synthesis of 2-amino-4H-chromene derivatives by MNPs@Cu as an effective and reusable magnetic nanocatalyst.

Authors:  Wanzheng Ma; Abdol Ghaffar Ebadi; Mostafa Shahbazi Sabil; Ramin Javahershenas; Giorgos Jimenez
Journal:  RSC Adv       Date:  2019-04-25       Impact factor: 4.036

3.  Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease.

Authors:  Arun K Ghosh; Jun Takayama; Yoann Aubin; Kiira Ratia; Rima Chaudhuri; Yahira Baez; Katrina Sleeman; Melissa Coughlin; Daniel B Nichols; Debbie C Mulhearn; Bellur S Prabhakar; Susan C Baker; Michael E Johnson; Andrew D Mesecar
Journal:  J Med Chem       Date:  2009-08-27       Impact factor: 7.446

Review 4.  An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.

Authors:  Thanigaimalai Pillaiyar; Manoj Manickam; Vigneshwaran Namasivayam; Yoshio Hayashi; Sang-Hun Jung
Journal:  J Med Chem       Date:  2016-02-29       Impact factor: 7.446

Review 5.  Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology.

Authors:  Lin-Sheng Zhuo; Ming-Shu Wang; Jing-Fang Yang; Hong-Chuang Xu; Wei Huang; Lu-Qing Shang; Guang-Fu Yang
Journal:  Top Curr Chem (Cham)       Date:  2021-04-22

6.  Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy.

Authors:  Arun K Ghosh; Kai Xi; Michael E Johnson; Susan C Baker; Andrew D Mesecar
Journal:  Annu Rep Med Chem       Date:  2007-02-01       Impact factor: 1.059

Review 7.  Synthetic and computational efforts towards the development of peptidomimetics and small-molecule SARS-CoV 3CLpro inhibitors.

Authors:  Abhik Paul; Arnab Sarkar; Sanjukta Saha; Avik Maji; Pritha Janah; Tapan Kumar Maity
Journal:  Bioorg Med Chem       Date:  2021-07-03       Impact factor: 3.641

8.  4-Chloro-N'-[(3Z)-2-oxo-2,3-di-hydro-1H-indol-3-yl-idene]benzohydrazide.

Authors:  Shaaban K Mohamed; Joel T Mague; Mehmet Akkurt; Abdel-Aal M Jaber; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-12-14

9.  Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.

Authors:  Hyun Lee; Shuyi Cao; Kirk E Hevener; Lena Truong; Joseph L Gatuz; Kavankumar Patel; Arun K Ghosh; Michael E Johnson
Journal:  ChemMedChem       Date:  2013-06-20       Impact factor: 3.466
  9 in total

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