BACKGROUND: The ability of beta blockers to improve left ventricular function has been demonstrated, but data on the effects on cardiac remodelling are limited. OBJECTIVE: To investigate, using cardiovascular magnetic resonance (CMR), the effects of carvedilol on left ventricular remodelling in patients with chronic stable heart failure and left ventricular systolic dysfunction caused by coronary artery disease. DESIGN: Randomised, double blind, placebo controlled study. SETTING: Chronic stable heart failure. PATIENTS AND INTERVENTION: 34 patients with chronic stable heart failure and left ventricular systolic function taking part in the CHRISTMAS trial (double blindcarvedilol v placebo) underwent CMR before randomisation and after six months of treatment. MAIN OUTCOME MEASURE: Left ventricular remodelling at six months. RESULTS: The carvedilol and placebo groups were well balanced at baseline, with no significant intergroup differences. Over the study period, there was a significant reduction in end systolic volume index (ESV(I)) and end diastolic volume index (EDV(I)) between the carvedilol and the placebo group (carvedilol -9 v placebo +3 ml/m2, p = 0.0004; carvedilol -8 v placebo 0 ml/m2, p = 0.05). The ejection fraction increased significantly between the groups (carvedilol +3% v placebo -2%, p = 0.003). CONCLUSIONS: Treatment of chronic stable heart failure with carvedilol results in significant improvement in left ventricular volumes and function. These effects might contribute to the benefits of carvedilol on mortality and morbidity in patients with chronic heart failure.
RCT Entities:
BACKGROUND: The ability of beta blockers to improve left ventricular function has been demonstrated, but data on the effects on cardiac remodelling are limited. OBJECTIVE: To investigate, using cardiovascular magnetic resonance (CMR), the effects of carvedilol on left ventricular remodelling in patients with chronic stable heart failure and left ventricular systolic dysfunction caused by coronary artery disease. DESIGN: Randomised, double blind, placebo controlled study. SETTING: Chronic stable heart failure. PATIENTS AND INTERVENTION: 34 patients with chronic stable heart failure and left ventricular systolic function taking part in the CHRISTMAS trial (double blind carvedilol v placebo) underwent CMR before randomisation and after six months of treatment. MAIN OUTCOME MEASURE: Left ventricular remodelling at six months. RESULTS: The carvedilol and placebo groups were well balanced at baseline, with no significant intergroup differences. Over the study period, there was a significant reduction in end systolic volume index (ESV(I)) and end diastolic volume index (EDV(I)) between the carvedilol and the placebo group (carvedilol -9 v placebo +3 ml/m2, p = 0.0004; carvedilol -8 v placebo 0 ml/m2, p = 0.05). The ejection fraction increased significantly between the groups (carvedilol +3% v placebo -2%, p = 0.003). CONCLUSIONS: Treatment of chronic stable heart failure with carvedilol results in significant improvement in left ventricular volumes and function. These effects might contribute to the benefits of carvedilol on mortality and morbidity in patients with chronic heart failure.
Authors: J N Cohn; M B Fowler; M R Bristow; W S Colucci; E M Gilbert; V Kinhal; S K Krueger; T Lejemtel; K A Narahara; M Packer; S T Young; T L Holcslaw; M A Lukas Journal: J Card Fail Date: 1997-09 Impact factor: 5.712
Authors: M R Bristow; E M Gilbert; W T Abraham; K F Adams; M B Fowler; R E Hershberger; S H Kubo; K A Narahara; H Ingersoll; S Krueger; S Young; N Shusterman Journal: Circulation Date: 1996-12-01 Impact factor: 29.690
Authors: E M Gilbert; W T Abraham; S Olsen; B Hattler; M White; P Mealy; P Larrabee; M R Bristow Journal: Circulation Date: 1996-12-01 Impact factor: 29.690
Authors: W S Colucci; M Packer; M R Bristow; E M Gilbert; J N Cohn; M B Fowler; S K Krueger; R Hershberger; B F Uretsky; J A Bowers; J D Sackner-Bernstein; S T Young; T L Holcslaw; M A Lukas Journal: Circulation Date: 1996-12-01 Impact factor: 29.690
Authors: M Packer; W S Colucci; J D Sackner-Bernstein; C S Liang; D A Goldscher; I Freeman; M L Kukin; V Kinhal; J E Udelson; M Klapholz; S S Gottlieb; D Pearle; R J Cody; J J Gregory; N E Kantrowitz; T H LeJemtel; S T Young; M A Lukas; N H Shusterman Journal: Circulation Date: 1996-12-01 Impact factor: 29.690
Authors: H Krum; J D Sackner-Bernstein; R L Goldsmith; M L Kukin; B Schwartz; J Penn; N Medina; M Yushak; E Horn; S D Katz Journal: Circulation Date: 1995-09-15 Impact factor: 29.690
Authors: M Packer; M R Bristow; J N Cohn; W S Colucci; M B Fowler; E M Gilbert; N H Shusterman Journal: N Engl J Med Date: 1996-05-23 Impact factor: 91.245
Authors: Kerryn W Reding; Aaron K Aragaki; Richard K Cheng; Ana Barac; Sylvia Wassertheil-Smoller; Jessica Chubak; Marian C Limacher; W Gregory Hundley; Ralph D'Agostino; Mara Z Vitolins; Theodore M Brasky; Laurel A Habel; Eric J Chow; Rebecca D Jackson; Chu Chen; April Morgenroth; Wendy E Barrington; Matthew Banegas; Matthew Barnhart; Rowan T Chlebowski Journal: Oncologist Date: 2020-04-06
Authors: Daniel G Kramer; Thomas A Trikalinos; David M Kent; George V Antonopoulos; Marvin A Konstam; James E Udelson Journal: J Am Coll Cardiol Date: 2010-07-27 Impact factor: 24.094
Authors: Edith Pituskin; Mark Haykowsky; John R Mackey; Richard B Thompson; Justin Ezekowitz; Sheri Koshman; Gavin Oudit; Kelvin Chow; Joseph J Pagano; Ian Paterson Journal: BMC Cancer Date: 2011-07-27 Impact factor: 4.430