Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The computational integrated myocyte: a view into the virtual heart.

Literature DB >> 15201177

The computational integrated myocyte: a view into the virtual heart.

James B Bassingthwaighte¹, Kalyan C Vinnakota.

Abstract

The presentation outlines an integrative approach for developing a computational model of cardiomyocytes. A modular approach is proposed, and strategies of linking the modules (intermediary metabolism, electrophysiology, and mechanics) of the model are presented. A strong recommendation is given toward an integrated system approach backed by experimental validation.

Mesh：

Year: 2004 PMID： 15201177 PMCID： PMC2864609 DOI： 10.1196/annals.1302.034

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

57 in total

Review 1. Regulation of contraction in striated muscle.

Authors: A M Gordon; E Homsher; M Regnier
Journal: Physiol Rev Date: 2000-04 Impact factor: 37.312

2. Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration.

Authors: J L Greenstein; R Wu; S Po; G F Tomaselli; R L Winslow
Journal: Circ Res Date: 2000-11-24 Impact factor: 17.367

3. Cardiac muscle fiber force versus length determined by a cardiac muscle crossbridge model.

Authors: T W Taylor; Y Goto; H Suga
Journal: Heart Vessels Date: 1992 Impact factor: 2.037

4. The modelling of a primitive 'sustainable' conservative cell.

Authors: James B Bassingthwaighte
Journal: Philos Trans A Math Phys Eng Sci Date: 2001-06 Impact factor: 4.226

5. Computational biology of the heart: from structure to function.

Authors: A McCulloch; J Bassingthwaighte; P Hunter; D Noble
Journal: Prog Biophys Mol Biol Date: 1998 Impact factor: 3.667

6. Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.

Authors: D Noble; A Varghese; P Kohl; P Noble
Journal: Can J Cardiol Date: 1998-01 Impact factor: 5.223

Review 7. Theoretical formalism for the sliding filament model of contraction of striated muscle. Part I.

Authors: T L Hill
Journal: Prog Biophys Mol Biol Date: 1974 Impact factor: 3.667

8. Computer simulation of entry into glycolysis and lactate output in the ischemic rat heart.

Authors: M C Kohn; D Garfinkel
Journal: J Mol Cell Cardiol Date: 1978-09 Impact factor: 5.000

9. Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: equations and parameter refinement.

Authors: P J Mulquiney; P W Kuchel
Journal: Biochem J Date: 1999-09-15 Impact factor: 3.857