| Literature DB >> 15196558 |
Simona Polo1, Salvatore Pece, Pier Paolo Di Fiore.
Abstract
Eukaryotic cells use endocytosis to internalise plasma membrane, surface receptors and their ligands, viruses and various extracellular soluble molecules. Endocytosis has been regarded as a long-term mechanism of signal attenuation via receptor clearance from the cell surface. However, additional, and quite unexpected, functions for endocytosis have emerged, which, together with its attenuation function, project a central role for this process in cellular homeostasis and control of proliferation. Subversion of endocytic control is thus predicted to play a causative role in hyperproliferative conditions, first and foremost cancer.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15196558 DOI： 10.1016/j.ceb.2004.02.003
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382