Literature DB >> 15196047

Transient species in the stepwise interconversion of NADH and NAD+.

Jerzy Gebicki1, Andrzej Marcinek, Jacek Zielonka.   

Abstract

Two mechanisms of the interconversion of NADH and NAD+ in the coenzyme itself and in its analogues are discussed: a one-step hydride transfer and a stepwise electron-proton-electron transfer. Direct characterization of the transient species in the stepwise process and inversion of the stability order of the keto and enol tautomers is presented. The nonenzymatic and enzyme-mediated reactions of selected pyridinium salts that affect the NADH <==>NAD+ equilibrium are discussed in terms of their potential cytotoxicity.

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Year:  2004        PMID： 15196047     DOI： 10.1021/ar030171j

Source DB:  PubMed          Journal:  Acc Chem Res        ISSN： 0001-4842            Impact factor:   22.384


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