OBJECTIVE: To study the effect on mammographic breast density of two different continuous combined regimens for hormone therapy. DESIGN: Randomized clinical study. SETTING:University hospital. PATIENT(S): Postmenopausal women without any previous history of breast disorder. INTERVENTION(S): The women received either estradiol valerate/dienogest or estradiol/norethisterone acetate. Mammograms and venous blood samples were obtained at baseline and after 6 months. MAIN OUTCOME MEASURE(S): Change in mammographic breast density. Correlations with levels of hormones, growth factors, and binding proteins. RESULT(S): An increase in mammographic density was recorded in approximately 50% of the women, and there were no differences between treatments. Increased density showed a positive correlation with estradiol, estrone, and sex hormone-binding globulin and showed a negative association to free T. Among hormonal factors, levels of free T were the most important for predicting increased density. CONCLUSION(S): Continuous combined hormone therapy with different progestogens has a marked impact on the breast.
RCT Entities:
OBJECTIVE: To study the effect on mammographic breast density of two different continuous combined regimens for hormone therapy. DESIGN: Randomized clinical study. SETTING: University hospital. PATIENT(S): Postmenopausal women without any previous history of breast disorder. INTERVENTION(S): The women received either estradiol valerate/dienogest or estradiol/norethisterone acetate. Mammograms and venous blood samples were obtained at baseline and after 6 months. MAIN OUTCOME MEASURE(S): Change in mammographic breast density. Correlations with levels of hormones, growth factors, and binding proteins. RESULT(S): An increase in mammographic density was recorded in approximately 50% of the women, and there were no differences between treatments. Increased density showed a positive correlation with estradiol, estrone, and sex hormone-binding globulin and showed a negative association to free T. Among hormonal factors, levels of free T were the most important for predicting increased density. CONCLUSION(S): Continuous combined hormone therapy with different progestogens has a marked impact on the breast.
Authors: Lusine Yaghjyan; Graham Colditz; Heather Eliassen; Bernard Rosner; Aleksandra Gasparova; Rulla M Tamimi Journal: Cancer Causes Control Date: 2018-06-25 Impact factor: 2.506
Authors: Carolyn Crandall; Shana Palla; Beth A Reboussin; Giske Ursin; Gail A Greendale Journal: Breast Cancer Res Date: 2005-09-22 Impact factor: 6.466