Adrian Vella1, Michael Camilleri, Robert A Rizza. 1. Division of Endocrinology & Metabolism, Department of Medicine, Mayo Clinic & Foundation, 200 First ST SW, Rochester, MN 55905, USA. vella.adrian@mayo.edu
Abstract
PURPOSE OF REVIEW: The development of incretin hormones and incretin analogues for the therapy of diabetes highlights the importance of the gastrointestinal tract in the maintenance of glucose tolerance. RECENT FINDINGS: The review focuses on recent information on the role of incretins and their breakdown products on insulin secretion, gastric emptying, and satiety. The importance of gastric emptying and its absorptive potential as well as of dietary composition on gastric emptying and glucose tolerance is highlighted. The concept of a portal glucose sensor in humans has been the subject of some controversy but has been recently revisited. SUMMARY: The gastrointestinal tract plays an important part in glucose tolerance. In this review we have examined how factors altering gastric emptying, insulin secretion in response to meal ingestion, and gastric emptying contribute to the maintenance and deterioration of glucose tolerance.
PURPOSE OF REVIEW: The development of incretin hormones and incretin analogues for the therapy of diabetes highlights the importance of the gastrointestinal tract in the maintenance of glucose tolerance. RECENT FINDINGS: The review focuses on recent information on the role of incretins and their breakdown products on insulin secretion, gastric emptying, and satiety. The importance of gastric emptying and its absorptive potential as well as of dietary composition on gastric emptying and glucose tolerance is highlighted. The concept of a portal glucose sensor in humans has been the subject of some controversy but has been recently revisited. SUMMARY: The gastrointestinal tract plays an important part in glucose tolerance. In this review we have examined how factors altering gastric emptying, insulin secretion in response to meal ingestion, and gastric emptying contribute to the maintenance and deterioration of glucose tolerance.
Authors: Torsten P Vahl; Benedikt A Aulinger; Eric P Smith; Deborah L Drazen; Yve Ulrich-Lai; Randy J Seeley; Stephen C Woods; David A D'Alessio Journal: Am J Physiol Endocrinol Metab Date: 2014-08-26 Impact factor: 4.310
Authors: Barbara Stoll; David A Horst; Liwei Cui; Xiaoyan Chang; Kenneth J Ellis; Darryl L Hadsell; Agus Suryawan; Ashish Kurundkar; Akhil Maheshwari; Teresa A Davis; Douglas G Burrin Journal: J Nutr Date: 2010-10-27 Impact factor: 4.798
Authors: Galina Smushkin; Airani Sathananthan; Chiara Dalla Man; Alan R Zinsmeister; Michael Camilleri; Claudio Cobelli; Robert A Rizza; Adrian Vella Journal: J Clin Endocrinol Metab Date: 2011-11-16 Impact factor: 5.958